Despite the success of genome-wide association studies (GWASs) in identifying loci associated
with common diseases, a substantial proportion of the causality remains unexplained. …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

There are some mammalian alleles that display the unusual characteristic of variable
expressivity in the absence of genetic heterogeneity. It has recently become evident that this is …

DNA methylation is the most stable type of epigenetic modification modulating the transcriptional
plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-…

There is a growing realization that some aging-associated phenotypes/diseases have an
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during …

Phenotypic variation that cannot be explained by genetic or environmental heterogeneity
has intrigued geneticists for decades. The molecular basis of this phenomenon, however, is …

DNA methylation is an indispensible epigenetic modification required for regulating the
expression of mammalian genomes. Immunoprecipitation-based methods for DNA methylome …

The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA
methylation phenomena. Occurring naturally on cytosine bases at cytosine–guanine …

We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide
tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, …

Last October, scientists gathered in Amsterdam to celebrate the start of BLUEPRINT (http://www.
blueprint-epigenome. eu/), an EU-funded consortium that will generate epigenomic …