[HTML][HTML] Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction

SS Weigt, V Palchevskiy… - The Journal of clinical …, 2017 - Am Soc Clin Investig
Inflammasomes are high-molecular-weight cytosolic complexes that mediate the activation
of caspases. There are many inflammasomes, and each is influenced by a unique pattern-…

Escherichia coli Competence Gene Homologs Are Essential for Competitive Fitness and the Use of DNA as a Nutrient

V Palchevskiy, SE Finkel - Journal of bacteriology, 2006 - Am Soc Microbiol
Natural genetic competence is the ability of cells to take up extracellular DNA and is an
important mechanism for horizontal gene transfer. Another potential benefit of natural …

Non-tuberculous mycobacterium infection after lung transplantation is associated with increased mortality

…, SS Weigt, A Derhovanessian, V Palchevskiy… - The Journal of heart and …, 2011 - Elsevier
Background Pulmonary non-tuberculous mycobacterial (NTM) infection is relatively common
after lung transplantation, but the effect on mortality remains undetermined. Herein we …

Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation

…, X Wang, SS Weigt, V Palchevskiy… - American journal of …, 2013 - atsjournals.org
Rationale: Pseudomonas aeruginosa is the most commonly isolated gram-negative
bacterium after lung transplantation and has been shown to up-regulate glutamic acid–leucine–…

Altered exosomal RNA profiles in bronchoalveolar lavage from lung transplants with acute rejection

…, ST Poynter, C Briones, V Palchevskiy… - American journal of …, 2015 - atsjournals.org
Rationale: The mechanism by which acute allograft rejection leads to chronic rejection
remains poorly understood despite its common occurrence. Exosomes, membrane vesicles …

[HTML][HTML] CD4+ CD25hiFoxp3+ cells exacerbate bleomycin-induced pulmonary fibrosis

SZ Birjandi, V Palchevskiy, YY Xue, S Nunez… - The American journal of …, 2016 - Elsevier
Idiopathic pulmonary fibrosis is a fatal lung disease with a median survival of 2 to 5 years. A
decade of studies has downplayed inflammation contributing to its pathogenesis. However, …

[HTML][HTML] Endotype–phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease

…, SS Weigt, R Saggar, V Palchevskiy… - …, 2019 - thelancet.com
Background Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD
phenotype (PF-ILD), with similar persistent lung function decline suggesting common …

[HTML][HTML] Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis

V Palchevskiy, N Hashemi, SS Weigt, YY Xue… - Fibrogenesis & tissue …, 2011 - Springer
Background Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with
the formation of non-necrotizing granulomas. CC chemokines (chemokine (CC motif) ligand …

CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction

MY Shino, SS Weigt, N Li, V Palchevskiy… - American journal of …, 2013 - atsjournals.org
Rationale: After lung transplantation, insults to the allograft generally result in one of four
histopathologic patterns of injury: (1) acute rejection, (2) lymphocytic bronchiolitis, (3) …

[HTML][HTML] The role of TGF-β in the association between primary graft dysfunction and bronchiolitis obliterans syndrome

A DerHovanessian, SS Weigt, V Palchevskiy… - American Journal of …, 2016 - Elsevier
Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome
(BOS) following lung transplantation; however, the mechanism for any such association is …