User profiles for V. Chandrabaln

Vishnu V Chandrabalan

Head of Data Science and AI, Lancashire Teaching Hospitals NHS Foundation Trust
Verified email at lthtr.nhs.uk
Cited by 282

Molecular mechanisms regulating Proteinase‐Activated Receptors (PARs)

A Chandrabalan, R Ramachandran - The FEBS Journal, 2021 - Wiley Online Library
Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have emerged …

[HTML][HTML] Extracellular vesicles in liquid biopsies as biomarkers for solid tumors

B Irmer, S Chandrabalan, L Maas, A Bleckmann… - Cancers, 2023 - mdpi.com
Simple Summary During the past decade, liquid biopsy-related publications have increased
exponentially, demonstrating the great potential of screening body fluids for diagnosis, …

[HTML][HTML] The role of artificial intelligence technology in the care of diabetic foot ulcers: the past, the present, and the future

…, CJ Fernandez, V Chandrabalan… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Foot ulcers are common complications of diabetes mellitus and substantially increase the
morbidity and mortality due to this disease. Wound care by regular monitoring of the progress …

PowerCore: a program applying the advanced M strategy with a heuristic search for establishing core sets

…, HK Chung, GT Cho, KH Ma, D Chandrabalan… - …, 2007 - academic.oup.com
Motivation: Core sets are necessary to ensure that access to useful alleles or characteristics
retained in genebanks is guaranteed. We have successfully developed a computational tool …

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis

L Deng, F Costa, KJ Blake, S Choi, A Chandrabalan… - Cell, 2023 - cell.com
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …

[HTML][HTML] Serum amylase on the night of surgery predicts clinically significant pancreatic fistula after pancreaticoduodenectomy

LKP Velu, VV Chandrabalan, S Jabbar, DC McMillan… - HPB, 2014 - Elsevier
Objectives Drainage after pancreaticoduodenectomy (PD) remains controversial because the
risk for uncontrolled postoperative pancreatic fistula (POPF) must be balanced against the …

[HTML][HTML] Pre-operative cardiopulmonary exercise testing predicts adverse post-operative events and non-progression to adjuvant therapy after major pancreatic …

VV Chandrabalan, DC McMillan, R Carter, J Kinsella… - Hpb, 2013 - Elsevier
Background Surgery followed by chemotherapy is the primary modality of cure for patients
with resectable pancreatic cancer but is associated with significant morbidity. The aim of the …

Antibiotic use in acute pancreatitis: an audit of current practice in a tertiary centre

M Baltatzis, JM Mason, V Chandrabalan, P Stathakis… - Pancreatology, 2016 - Elsevier
Introduction Intravenous antibiotic prophylaxis is not recommended in acute pancreatitis.
According to current international guidelines antibiotics together with further intervention should …

Discovery of Ghrelin (1–8) Analogues with Improved Stability and Functional Activity for PET Imaging

MD Childs, A Chandrabalan, D Hodgson… - ACS Pharmacology & …, 2023 - ACS Publications
The highest affinity ghrelin-based analogue for fluorine-18 positron emission tomography, [Inp
1 ,Dpr 3 (6-FN),1Nal 4 ,Thr 8 ]ghrelin(1–8) amide (1), has remarkable subnanomolar …

A cohort study of duplicate faecal immunochemical testing in patients at risk of colorectal cancer from North-West England

N Hunt, C Rao, R Logan, V Chandrabalan, J Oakey… - BMJ open, 2022 - bmjopen.bmj.com
Objectives We sought to investigate if duplicate faecal immunochemical testing (FIT) sampling
improves the negative and positive predictive value of patients thought to be at risk of …