Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting …
T Lesuffleur, A Barbat, E Dussaulx, A Zweibaum - Cancer research, 1990 - AACR
The purpose of this work was to investigate whether the phenomenon of metabolic
adaptation of HT-29 cells to glucose deprivation and subsequent emergence of differentiated …
adaptation of HT-29 cells to glucose deprivation and subsequent emergence of differentiated …
Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations
T Lesuffleur, N Porchet, JP Aubert… - Journal of cell …, 1993 - journals.biologists.com
… 16E immunoreact with the polyclonal antibodies against gastric mucins (L-56) used in
this study (Lesuffleur et al., 1991b). Although further compositional studies are required to …
this study (Lesuffleur et al., 1991b). Although further compositional studies are required to …
Resistance of colon cancer cells to long‐term 5‐fluorouracil exposure is correlated to the relative level of Bcl‐2 and Bcl‐XL in addition to Bax and p53 status
…, JM Lacorte, C Staedel, T Lesuffleur - … journal of cancer, 2002 - Wiley Online Library
Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We
report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines …
report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines …
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon
…, A Grodet, M Fay, D Biard, T Lesuffleur… - … and cellular biology, 2010 - Taylor & Francis
… The Student t test and one-way analysis of variance with a Tukey-Kramer multiple-… of PTEN
is associated with the resistance of human T-cell lymphoblastic leukemias and lymphomas to …
is associated with the resistance of human T-cell lymphoblastic leukemias and lymphomas to …
[HTML][HTML] CARD15/NOD2 is required for Peyer's patches homeostasis in mice
…, V Ollendorff, M Heyman, S Bonacorsi, T Lesuffleur… - PloS one, 2007 - journals.plos.org
… As T-cells are known to play a pivotal role in CD, we further analyzed the CD3 + … Finally,
we investigated the phenotype of CD4 + T-cells present in the PPs and spleens by examining …
we investigated the phenotype of CD4 + T-cells present in the PPs and spleens by examining …
Long-term follow-up after bariatric surgery in a national cohort
J Thereaux, T Lesuffleur, M Païta… - Journal of British …, 2017 - academic.oup.com
Background Lifelong medical follow-up is mandatory after bariatric surgery. The aim of this
study was to assess the 5-year follow-up after bariatric surgery in a nationwide cohort of …
study was to assess the 5-year follow-up after bariatric surgery in a nationwide cohort of …
Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells
…, M Figeac, M Hebbar, CH Lecellier, T Lesuffleur… - Cancer research, 2010 - AACR
Metastasis and drug resistance are major problems in cancer chemotherapy. The purpose
of this work was to analyze the molecular mechanisms underlying the invasive potential of …
of this work was to analyze the molecular mechanisms underlying the invasive potential of …
Mucins in normal and neoplastic human gastrointestinal tissues
T Lesuffleur, A Zweibaum, FX Real - Critical reviews in oncology …, 1994 - Elsevier
Mucins are glycoproteins characterized by a high molecular mass (> 2 x lo6 Da), high
carbohydrate content (50-80% of their mass) and heterogeneity involving both the apomucin (also …
carbohydrate content (50-80% of their mass) and heterogeneity involving both the apomucin (also …
Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas
…, J Chambaz, M Lacasa, T Lesuffleur - … journal of cancer, 2003 - Wiley Online Library
A better understanding of the mechanisms by which colon tumor cells are able to survive
exposure to drugs would be valuable for the development of new therapeutic strategies. We …
exposure to drugs would be valuable for the development of new therapeutic strategies. We …
[HTML][HTML] The economic burden of disease in France from the National Health Insurance Perspective: the healthcare expenditures and conditions mapping used to …
…, P Constantinou, J Drouin, D Lastier, T Lesuffleur… - Medical care, 2022 - journals.lww.com
Background: Identifying the most frequently treated and the costliest health conditions is
essential for prioritizing actions to improve the resilience of health systems. Objectives: …
essential for prioritizing actions to improve the resilience of health systems. Objectives: …