… epidermal keratinocytes, activate group 2 innate lymphoid cells (ILC2) and T helper 2 (Th2)
cells at the lesion site, inducing type 2 immune responses. Such immune responses lead to …

Background Cow’s milk (CM) is an increasingly common cause of severe allergic reactions,
but there is uncertainty with respect to severity of reactions at low-level CM exposure, as well …

Background There are some biomarkers for asthma diagnosis but they are often difficult in
clinical use, particularly in pediatric cases. Periostin is an extracellular matrix protein, …

… Superantigens activate T cells in a nonspecific manner against antigens. Several studies …
antigens of T cells from healthy donors. Intracutaneous injection of SEB induces a T cell–…

… This is an X-linked recessive inherited disease caused by an abnormality of the WASP gene
and is characterized by immunodeficiency (T-cell dysfunction), thrombopenia, and refractory …

… However, the effects of long-term treatment with omalizumab in this population haven't
been well investigated. The objective of this study is to evaluate the long-term safety, efficacy, …

Mast cells (MCs) and eosinophils are thought to play important roles in evoking allergic
inflammation. Cell-type–specific gene expression was screened among 12 000 genes in human …

Cough and sputum are common complaints at outpatient visits. In this digest version, we
provide a general overview of these two symptoms and discuss the management of acute (up to …

Background: This study was aimed at evaluating the efficacy and safety of oral immunotherapy
(OIT) in children with severe cow's milk allergy. Methods: The subjects comprised 28 …

Background: Omalizumab has demonstrated clinical benefits in children with moderate to
severe allergic asthma. However, no studies have been performed in Japanese asthmatic …