Treating asthma means treating airway smooth muscle cells

S Zuyderduyn, MB Sukkar, A Fust… - European …, 2008 - Eur Respiratory Soc
Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway …

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

SC Mack, H Witt, RM Piro, L Gu, S Zuyderduyn… - Nature, 2014 - nature.com
Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy comprises …

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

…, S Zuyderduyn, GD Bader, S VandenBerg… - Nature, 2014 - nature.com
… ): 94 C for 3 min, followed by 10 cycles of 94 C for 10 s, 62 C for 30 s and 68 C for 6 min and
25 cycles of 94 C for 10 s, 60 C for 30 s and 68 C for 7 min, followed by a final cycle of 72 C …

Divergent clonal selection dominates medulloblastoma at recurrence

AS Morrissy, L Garzia, DJH Shih, S Zuyderduyn… - Nature, 2016 - nature.com
The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …

[PDF][PDF] A SAGE approach to discovery of genes involved in autophagic cell death

…, RJ Varhol, SM Coughlin, SD Zuyderduyn… - Current Biology, 2003 - cell.com
… described previously in the salivary gland, we identified additionalgenesassociated,inothertissues,withapotein-methionine-S-oxide
reductase, both peaked in gene expression at 20 hr …

Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis

BR Steen, S Zuyderduyn, DL Toffaletti, M Marra… - Eukaryotic …, 2003 - Am Soc Microbiol
Cryptococcus neoformans, an encapsulated basidiomycete fungus of medical importance,
is capable of crossing the blood-brain barrier and causing meningitis in both …

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers

…, RHE Cloots, GM Möller, KR Bracke, S Zuyderduyn… - Thorax, 2009 - thorax.bmj.com
Background: Chronic obstructive pulmonary disease (COPD) is characterised by an
abnormal inflammatory reaction of the lungs involving activation of epithelial cells. Leptin is a …

Iron‐regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans

…, CA D'Souza, BR Steen, SD Zuyderduyn… - Molecular …, 2005 - Wiley Online Library
… As expected, one of the most abundant tags under LIM conditions matched an iron
permease with similarity to the FTR1 gene of S. cerevisiae and the fip1+ gene of …

Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans

BR Steen, T Lian, S Zuyderduyn… - Genome …, 2002 - genome.cshlp.org
… On the other hand, a comparison of our results with the changes in transcript levels observed
for S. cerevisiae genes at 25C and 37C (as measured by microarray analysis; Gasch et al. …

The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells

S Zuyderduyn, DK Ninaber, PS Hiemstra… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Human airway smooth muscle (HASM) cells release various chemokines
that are involved in recruitment of inflammatory cells, which can be found within or in the …