Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans
G Gouspillou, N Sgarioto, S Kapchinsky… - The FASEB …, 2014 - Wiley Online Library
Mitochondrial dysfunction is implicated in skeletal muscle atrophy and dysfunction with
aging, with strong support for an increased mitochondrial‐mediated apoptosis in sedentary …
aging, with strong support for an increased mitochondrial‐mediated apoptosis in sedentary …
[HTML][HTML] Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle
…, S Spendiff, RT Jagoe, S Aare, S Kapchinsky… - Skeletal muscle, 2016 - Springer
… Amplification was performed on a thermal cycler under the following conditions: 3 min at
93 C; 30 cycles of 93 C for 30 s, 58 C for 30 s, and 68 C for 12 min; with an additional 5 s for …
93 C; 30 cycles of 93 C for 30 s, 58 C for 30 s, and 68 C for 12 min; with an additional 5 s for …
Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease
…, HR Gosker, AMWJ Schols, S Kapchinsky… - American journal of …, 2013 - atsjournals.org
Rationale: Locomotor muscle atrophy develops in patients with chronic obstructive
pulmonary disease (COPD) partly because of increased protein degradation by the ubiquitin-…
pulmonary disease (COPD) partly because of increased protein degradation by the ubiquitin-…
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians
…, ME Filion, R Glicksman, S Kapchinsky… - The Journal of …, 2016 - Wiley Online Library
… The cDNA was amplified at 95C for 10 min followed by 40 cycles of 95C for 15 s and 55C
for 60 s, using Power SYBR® Green PCR Master Mix (Life Technologies). All real time PCRs …
for 60 s, using Power SYBR® Green PCR Master Mix (Life Technologies). All real time PCRs …
Smoke‐induced neuromuscular junction degeneration precedes the fibre type shift and atrophy in chronic obstructive pulmonary disease
S Kapchinsky, M Vuda, K Miguez… - The Journal of …, 2018 - Wiley Online Library
… The cDNA was amplified at 95C for 10 min followed by 40 cycles of 95C for 15 s and 55C
for 60 s. All real time PCR experiments were performed in triplicate and melt curve analysis for …
for 60 s. All real time PCR experiments were performed in triplicate and melt curve analysis for …
[HTML][HTML] Eccentric ergometer training promotes locomotor muscle strength but not mitochondrial adaptation in patients with severe chronic obstructive pulmonary …
NJ MacMillan, S Kapchinsky, Y Konokhova… - Frontiers in …, 2017 - frontiersin.org
… of 4 s with the knees flexed at 60. After a 10 min rest, patients were asked to perform five
sequential volitional maximal contractions over a range of motion from 15 to 100 at 60/s to …
sequential volitional maximal contractions over a range of motion from 15 to 100 at 60/s to …
Effect of eccentric versus concentric exercise training on mitochondrial function
…, S Doutreleau, J Bouitbir, J Zoll, S Kapchinsky… - Muscle & …, 2014 - Wiley Online Library
Introduction: The effect of eccentric (ECC) versus concentric (CON) training on metabolic
properties in skeletal muscle is understood poorly. We determined the responses in oxidative …
properties in skeletal muscle is understood poorly. We determined the responses in oxidative …
Addressing assumptions for the use of non-invasive cardiac output measurement techniques during exercise in COPD
H Perrault, R Richard, S Kapchinsky… - COPD: Journal of …, 2016 - Taylor & Francis
The multifactorial functional limitation of COPD increasingly demonstrates the need for an
integrated circulatory assessment. In this study cardiac output (Qc) derived from non-inert (CO …
integrated circulatory assessment. In this study cardiac output (Qc) derived from non-inert (CO …
B96 HIGHLIGHTS IN PULMONARY REHABILITATION: 2013: Eccentric Cycling Improves The Metabolic Profile Of Lower Limb Muscle In Severe COPD
S Kapchinsky, P Rozakis, NJ MacMillan… - American Journal of …, 2014 - search.proquest.com
Methods: 15 COPD patients (66±6y, FEV1= 39.2±9.9% pred) were randomized into a
conventional (CON) or ECC cycling program for 10 weeks. Training consisted of 30min sessions, …
conventional (CON) or ECC cycling program for 10 weeks. Training consisted of 30min sessions, …
The effects of eccentric and concentric exercise training on muscle strength in COPD: Preliminary results
R Sena, J Baril, S Kapchinsky, N MacMillan, DV Rocha… - 2012 - Eur Respiratory Soc
Since in eccentric exercise greater force is produced at a reduced oxygen cost, this modality
of exercise could be attractive for pulmonary rehabilitation of severe COPD patients. …
of exercise could be attractive for pulmonary rehabilitation of severe COPD patients. …