User profiles for S. Boscardin

Silvia Beatriz Boscardin

Parasitology Department, University of São Paulo
Verified email at usp.br
Cited by 3196

[HTML][HTML] Adjuvants: Classification, Modus Operandi, and Licensing

…, VAS Lunardelli, FC Coirada, SB Boscardin… - Journal of immunology …, 2016 - hindawi.com
… of mycobacteria’s cell wall required for the efficacy of complete Freund’s adjuvant [133]. …
developed and tested in the RTS,S (Plasmodium falciparum circumsporozoite protein) vaccine …

The dengue virus non-structural 1 protein: risks and benefits

JH Amorim, RP dos Santos Alves, SB Boscardin… - Virus research, 2014 - Elsevier
The dengue virus (DENV) non-structural 1 (NS1) protein plays a critical role in viral RNA
replication and has a central position in DENV pathogenesis. DENV NS1 is a glycoprotein …

Chagas' disease: an update on immune mechanisms and therapeutic strategies

SB Boscardin, ACT Torrecilhas… - Journal of cellular …, 2010 - Wiley Online Library
… cruzi’s success in maintaining its life cycle is dependent on its capacity to cause chronic
infection … Generally, the absence of some component(s) of the immune response leads to greater …

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites

K Arun Kumar, G Sano, S Boscardin, RS Nussenzweig… - Nature, 2006 - nature.com
Malaria infection starts when mosquitoes inject sporozoites into the skin. The parasites
enter the blood stream and make their way to the liver where they develop into the exo-…

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses

SB Boscardin, JCR Hafalla, RF Masilamani… - The Journal of …, 2006 - rupress.org
Resistance to several prevalent infectious diseases requires both cellular and humoral immune
responses. T cell immunity is initiated by mature dendritic cells (DCs) in lymphoid organs…

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

…, Y Do, C Cheong, H Koh, SB Boscardin… - Journal of Experimental …, 2009 - rupress.org
Presumptive dendritic cells (DCs) bearing the CD11c integrin and other markers have
previously been identified in normal mouse and human aorta. We used CD11c promoter–…

Poly (I: C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP …

K Tewari, BJ Flynn, SB Boscardin, K Kastenmueller… - Vaccine, 2010 - Elsevier
… Currently, a phase III efficacy trial is underway using the RTS,S vaccine. RTS,S is a complex
formulation comprised of two polypeptide chains of Pf CSP (amino acid 207–395) linked to …

Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

…, M Yuda, S Dartevelle, F Traincard, SB Boscardin… - Nature …, 2018 - nature.com
… Images represent maximal projections of the SPZ trajectories (red) during 60 s. The initial
position of each parasite is represented in yellow. Representative results of three independent …

CD4+ CD25+ Foxp3+ Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host …

…, MS Bastos, SC Rocha, SB Boscardin… - Infection and …, 2010 - Am Soc Microbiol
Clearing blood-stage malaria parasites without inducing major host pathology requires a
finely tuned balance between pro- and anti-inflammatory responses. The interplay between …

[HTML][HTML] Targeting the non-structural protein 1 from dengue virus to a dendritic cell population confers protective immunity to lethal virus challenge

…, LCS Ferreira, AMB Alves, SB Boscardin - PLoS neglected …, 2013 - journals.plos.org
Dengue is the most prevalent arboviral infection, affecting millions of people every year.
Attempts to control such infection are being made, and the development of a vaccine is a World …