Lung barrier protection by Sphingosine-1 Phosphate (S1P) has been demonstrated
experimentally, but recent evidence suggests barrier disruptive properties of high systemic S1P …

Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate
is involved in the regulation of vascular permeability and immune responses. However, the …

The cytosolic nucleotide oligomerization domain (NOD)-like receptors NOD1 and NOD2 are
important contributors to the intracellular recognition of pathogens including Chlamydophila …

Results: S1P was reduced in serum of patients and mice with pneumonia. Following
infection, pulmonary S1P-levels and mRNA S. pn. expression of SphK1 and S1P receptor 2 (S1PR2…

Heart function requires sophisticated regulatory networks to orchestrate organ development,
physiological responses, and environmental adaptation. Until recently, it was thought that …

(1) Background: Hyperbaric oxygen (HBO) exposure induces oxidative stress that may lead
to DNA damage, which has been observed in human peripheral blood lymphocytes or non-…

The educational environment has been increasingly acknowledged as vital for high-quality
medical education. As a result, several instruments have been developed to measure …

MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that function
as “fine-tuning” tools of gene expression in development and tissue homeostasis. Their …

Background Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of
chromosome 7, loss of chromosome 10, and aberrantly activated receptor tyrosine kinase …