… Dr Lobo reported receiving personal fees for the conduct of the study as the principal
investigator at FUNFARME. Dr Barie reported personal fees from AKPA America during the conduct …

Background Molnupiravir is an oral prodrug of β-D-N4-hydroxycytidine, active against SARS-CoV-2
in vitro and in animal models. We report data from the phase 2 component of MOVe-…

Background Vilobelimab, an anti-C5a monoclonal antibody, was shown to be safe in a
phase 2 trial of invasively mechanically ventilated patients with COVID-19. Here, we aimed to …

Purpose Trials of tocilizumab in patients with severe COVID-19 pneumonia have
demonstrated mixed results, and the role of tocilizumab in combination with other treatments is …

Background End-of-life practices vary among intensive care units (ICUs) worldwide.
Differences can result in variable use of disproportionate or non-beneficial life-sustaining …

Introduction Noninvasive ventilation (NIV), as a weaning-facilitating strategy in predominantly
chronic obstructive pulmonary disease (COPD) mechanically ventilated patients, is …

The evaluation and initial management of patients with acute kidney injury (AKI) should
include:(1) an assessment of the contributing causes of the kidney injury,(2) an assessment of …

PURPOSE: To determine the effect of surrounding tissue type on coagulation necrosis from
radiofrequency (RF) ablation in a homogeneous animal tumor model. MATERIALS AND …

Introduction Recognition of patterns of organ failure may be useful in characterizing the
clinical course of critically ill patients. We investigated the patterns of early changes in organ …

Introduction Optimal fluid management is crucial for patients who undergo major and prolonged
surgery. Persistent hypovolemia is associated with complications, but fluid overload is …