Background: Many epidemiologic studies have found an association between physical activity
and breast cancer risk, although this has not been a consistent finding. Methods: Studies …

Effective predictive biomarkers are needed to enable personalized medicine and increase
treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and …

Background and Aims Patients with inflammatory bowel disease (IBD) have an increased
risk of colorectal cancer (CRC). We performed a systematic review and meta-analysis to …

Objective To evaluate mortality and morbidity in a large cohort of twin pregnancies according
to chorionicity. We aimed to estimate the optimal time of delivery. Design Historical cohort …

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) blockade is effective in a subset of
patients with several tumor types, but predicting patient benefit using approved diagnostics is …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Immune checkpoint inhibitors (ICIs), by reinvigorating CD8 + T cell mediated immunity, have
revolutionized cancer therapy. Yet, the systemic CD8 + T cell distribution, a potential …

Purpose: To provide proof of principle of safety, breast tumor–specific uptake, and positive
tumor margin assessment of the systemically administered near-infrared fluorescent tracer …

In vitro drug tests using patient-derived stem cell cultures offer opportunities to individually
select efficacious treatments. Here, we provide a study that demonstrates that in vitro drug …

The developmental origins hypothesis proposes that undernutrition during early development
is associated with an increased type 2 diabetes risk in adulthood. We investigated the …