Extracellular RNA (exRNA) has recently expanded as a highly important area of study in
biomarker discovery and cancer therapeutics. exRNA consists of diverse RNA subpopulations …

Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in
the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their …

Glioblastoma is the most prevalent and aggressive primary brain tumour for which total
tumour lysate-pulsed dendritic cell vaccination is currently under clinical evaluation. …

Background Three-dimensional visualization of the brain vasculature and its interactions with
surrounding cells may shed light on diseases where aberrant microvascular organization …

Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed
to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-…

Tumors that lack T cell infiltration are less likely to respond to immune checkpoint inhibition
and could benefit from cancer vaccination for the initiation of anti-tumor T cell responses. An …

Background In the last decades enormous efforts have been made to develop therapeutic
interventions that boost antitumor immunity, including adoptive cell transfer, anti‐cancer …

Background Glioblastomas manipulate the immune system both locally and systemically, yet,
glioblastoma-associated changes in peripheral blood immune composition are poorly …

To assess the contribution of right ventricular (RV) trabeculae and papillary muscles (TPM)
to RV mass and volumes in controls and patients with pulmonary arterial hypertension (PAH). …

Background Glioblastoma (GBM) is the most common and deadliest form of brain cancer in
adults. Standard treatment, consisting of surgery and radiochemotherapy, only provides a …