The cornerstone of tuberculosis management is a 6‐month course of isoniazid, rifampicin,
pyrazinamide and ethambutol. Compliance is crucial for curing tuberculosis. Adverse effects …

BACKGROUND: Incorrect usage of inhaler devices might have a major influence on the
clinical effectiveness of the delivered drug. This issue is poorly addressed in management …

Although the principles of asthma management are well established in Europe, the available
data indicate that asthma in patients is not well controlled. Many patients derive incomplete …

Background Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor
prognosis. Methods We conducted a double-blind, randomized, placebo-controlled multicenter …

Background Inhaled drug delivery is the cornerstone treatment for asthma and chronic
obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, …

Inspiratory muscle weakness in patients with COPD is of major clinical relevance. For instance,
maximum inspiratory pressure generation is an independent determinant of survival in …

The phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is associated
with all three major radiation resistance mechanisms: intrinsic radiosensitivity, tumor cell …

Objective Lung cancer patients report among the highest distress rates of all cancer patients.
Partners report similar distress rates. The present study examined the effectiveness of …

In this study, 2275 clinical isolates of 49 species of non-tuberculous mycobacteria isolated
in The Netherlands were subjected to standardised drug susceptibility testing using the …

The esat-6 and cfp-10 genes are essential for virulence in Mycobacterium tuberculosis. Among
nontuberculous mycobacteria, we found these genes only in M. kansasii, M. szulgai, M. …