Objective The Centre promotes research and provides an evidence base for the international
community, both on the burden of disease and health issues related to disasters and …

… minimum trough TAC trough concentrations (P = 0.021). A … effects (P = 0.001) but not with
organ rejection (P = 0.323). … increasing incidence of adverse effects (P = 0.046) using logistical …

Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

… substrates for P-glycoprotein (P-gp), the product of the multidrug resistance (MDR1) gene [
18 ]. P-… The gastrointestinal absorption of P-gp substrates is inversely proportional to the P-gp …

… As there is a large variance in MIC values for different bacteria, we considered the MICs
for problematic pathogens, such as P. aeruginosa, commonly isolated in ICU patients, as the …

OBJECTIVE: The aim of this study was to determine the distribution of plasma total
homocysteine (tHcy) concentrations in type 2 diabetic patients and to assess whether high tHcy …

… Simulation with doses calculated by using the IBW showed that only 35 (47%) patients
would have reached a peak >64 μg/ml (P < 0.01 compared with a regimen established by using …

… p values less than 0.05 were considered statistically significant. All values are expressed
as median and range unless otherwise stated. Multiple regression analysis models were used …

When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

… be made (P <… P values are those of P >|t| (ie, the probability of obtaining a greater absolute
t value by chance alone if there is no difference between pairs or sample means). This is the P …