Methods This paper arose from an extensive literature review undertaken in developing the
Canadian Healthy Infant Longitudinal Development (CHILD) study, a multicentre national …

Although pulmonary function testing plays a key role in the diagnosis and management of
chronic pulmonary conditions in children under 6 years of age, objective physiologic …

Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple-…

… group (P = 0.002; 95% CI, 2.4 to 196.0), 3.9 times more likely than the atopy only group (P
= 0.0429; 95% CI, 1.09 to 14.5), and 5.4 times more likely than the wheeze only group (P = …

Inert gas washout tests, performed using the single- or multiple-breath washout technique,
were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, …

Objective Dysbiosis of the infant gut microbiota may have long‐term health consequences.
This study aimed to determine the impact of maternal intrapartum antibiotic prophylaxis ( IAP ) …

This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to summarise …

Background The gut microbiota is established during infancy and plays a fundamental role
in shaping host immunity. Colonization patterns may influence the development of atopic …

Breastmilk contains a complex community of bacteria that may help seed the infant gut
microbiota. The composition and determinants of milk microbiota are poorly understood. Among …

… Using another ratio to represent gut microbiota maturity in the current study, pet exposure
was linked to a higher F/P ratio following vaginal birth in the absence of maternal IAP. Of note, …