NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

… Recently, however, Hatton and Paoletti [40 • ] have been able to overcome this difficulty
and isolate recombinant triheteromeric receptors using an approach combining mutagenesis …

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology.
The recent development of powerful tools, including zinc-sensitive fluorescent probes, …

… In this study, patients treated with pemetrexed had a significantly lower rate of alopecia (P
< .001) and a trend toward lower rates of grade 3 or 4 diarrhea (P = .069) compared with …

… Median survival time in the pemetrexed/cisplatin arm was 12.1 months versus 9.3 months
in the control arm (P = .020, two-sided log-rank test). The hazard ratio for death of patients in …

Chronic obstructive pulmonary disease (COPD) is a disorder characterized by reduced
maximum expiratory flow and slow forced emptying of the lungs; features which do not change …

… In the continuous variable model, higher HER2 ECD was associated with a shorter PFS (P
< 0.001) in the capecitabine group, but not in the combination-therapy group (P = 0.12). Given …

Micromolar concentrations of extracellular Zn 2+ are known to antagonize native NMDA
receptors via a dual mechanism involving both a voltage-independent and a voltage-dependent …

Purpose: Brain metastases develop in one third of patients with advanced HER2+ breast
cancer. Effective therapy for patients with central nervous system (CNS) progression after …

It has long been known that the mammalian forebrain contains a subset of glutamatergic
neurons that sequester zinc in their synaptic vesicles. This zinc may be released into the …