[HTML][HTML] Mapping the human genetic architecture of COVID-19

…, PP España, P Hoffmann, P Bacher, P Suwalski… - Nature, 2021 - nature.com
… significance threshold after adjusting the threshold for multiple traits tested (P < 5 × 10 −8
/3). We report the unadjusted P values for each variant. We tested for heterogeneity between …

Validation of a predictive rule for the management of community-acquired pneumonia

A Capelastegui, PP Espana… - European …, 2006 - Eur Respiratory Soc
… The AUC of the CURB-65 was similar to the CRB-65 (AUC 0.870 versus 0.864, p = 0.44)
and to the PSI (AUC 0.870 versus 0.888, p = 0.12) with regard to prediction of pneumonia …

Development and validation of a clinical prediction rule for severe community-acquired pneumonia

PP España, A Capelastegui, I Gorordo… - American journal of …, 2006 - atsjournals.org
Rationale: Objective strategies are needed to improve the diagnosis of severe community-acquired
pneumonia in the emergency department setting. Objectives: To develop and …

Duration of antibiotic treatment in community-acquired pneumonia: a multicenter randomized clinical trial

A Uranga, PP España, A Bilbao… - JAMA internal …, 2016 - jamanetwork.com
… (90 of 162) in the intervention group at day 10 (P = .18) and 88.6% (132 of 150) in the control
group and 91.9% (147 of 162) in the intervention group at day 30 (P = .33). The mean (SD) …

Promoter methylation of the PTEN gene is a common molecular change in breast cancer

…, B Cantos, M Provencio, P España… - Genes …, 2004 - Wiley Online Library
… ERBB2 expression levels correlated with PTEN promoter hypermethylation (P = 0.012): 22
of 33 (… with promoter hypermethylation: T3 (P = 0.03) and histologic grade III (P = 0.009) were …

Cancer antigen 125 associated with multiple benign and malignant pathologies

C Miralles, M Orea, P Espana, M Provencio… - Annals of Surgical …, 2003 - Springer
Background:Cancer antigen (CA) 125 tumor-associated antigen is a high molecular
glycoprotein used for follow-up of epithelial ovarian cancer. The test is often requested as a …

Q fever (Coxiella burnetii)

PP España, A Uranga, C Cillóniz… - Seminars in respiratory …, 2020 - thieme-connect.com
Q fever is a zoonotic infectious disease caused by the Coxiella burnetii bacterium. It is an
obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an …

Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations

…, F Navarro, M Provencio, S San Martin, P Espana… - Cancer research, 1999 - AACR
… We considered P < 0.05 to be significant Statistical analyses were performed using the EPI-…
After digestion with restriction enzyme PstI, tumor DNA (T) and plasma DNA (P) amplified for …

Improvement of process-of-care and outcomes after implementing a guideline for the management of community-acquired pneumonia: a controlled before-and-after …

A Capelastegui, PP Espana… - Clinical infectious …, 2004 - academic.oup.com
… of antibiotic treatment (P < .001) and intravenous treatment (P < .001), better coverage of
atypical pathogens (P < .001), and improved appropriateness of antibiotic treatment (P < .001), …

Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival

…, L Sanfrutos, E Jareno, A Colas, P Espana… - Clinical Cancer …, 2002 - AACR
… We considered P ≤ 0.05 to be significant. For the survival study, DFS was the end point. … a
predictable value for DFS in our series (P = 0.8 and P = 0.5, respectively; data not shown). We …