The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

Cytokines are important mediators of the effects observed after the administration of endotoxin.
One of them, tumor necrosis factor, is particularly important since it plays a cardinal role …

… P Brouckaert … P<0.05, **P<0.01, ****P<0.0001, compared with PBS controls (except for
e), with LPS (only for e), or as indicated by horizontal lines … P Brouckaert …

Tumor necrosis factor α (TNFα) enhances proliferation of chemically-induced mammary
tumors and of T47D human cell line through not fully understood pathways. Here, we explored …

… Diphenyleneiodonium (DPI), a general inhibitor of NAD(P)H-dependent flavoenzymes
commonly used to inhibit NAD(P)H oxidase, inhibits mitochondrial ROS production just as …

Tumor necrosis factor (TNF) was discovered in the middle 1970s by the research group of Old
(Carswell et al. 1975; Old 1988) as the result of a long search for the mechanisms …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

… P < 0.0001 compared with PAF in WT mice. (B) Western blot for phosphorylated eNOS (p-eNOS)
in kidney homogenates of individual mice 7 or 15 minutes after PAF injection. Where …

… route and the paralesional (p.1.) way as a local one. By p.1. injection we understand an SC
injection near the site of the tumour but outside the tumour nodule. 1.p. injections were made …

THE remarkable ability of tumour necrosis factor (TNF), especially in combination with
interferon, selectively to kill or inhibit malignant cell lines is so far unmatched by any other …