User profiles for P. J. Wolters

Paul Wolters

UCSF
Verified email at ucsf.edu
Cited by 23465

Pathogenesis of idiopathic pulmonary fibrosis

PJ Wolters, HR Collard, KD Jones - Annual Review of Pathology …, 2014 - annualreviews.org
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with
aging that is characterized by the histopathological pattern of usual interstitial pneumonia. …

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

PJ Wolters, TS Blackwell, O Eickelberg… - The Lancet …, 2018 - thelancet.com
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically fatal lung
disease characterised by subpleural fibrosis, subepithelial fibroblast foci, and microscopic …

Inflection points in sepsis biology: from local defense to systemic organ injury

…, MA Matthay, PJ Wolters - American Journal of …, 2012 - journals.physiology.org
Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that lead to …

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

…, A Hsu, S Chak, RP Naikawadi, PJ Wolters… - Nature …, 2019 - nature.com
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

KK Kim, MC Kugler, PJ Wolters… - Proceedings of the …, 2006 - National Acad Sciences
Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain unclear.
Although there is in vitro evidence of lung alveolar epithelial-to-mesenchymal transition (…

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

…, K Clément, JN Glickman, GK Sukhova, PJ Wolters… - Nature medicine, 2009 - nature.com
Although mast cell functions have classically been related to allergic responses 1 , 2 , 3 ,
recent studies indicate that these cells contribute to other common diseases such as multiple …

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

…, D Lynch, S Groshong, HR Collard, PJ Wolters… - Nature …, 2013 - nature.com
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic
idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up …

Mast cells promote atherosclerosis by releasing proinflammatory cytokines

J Sun, GK Sukhova, PJ Wolters, M Yang, S Kitamoto… - Nature medicine, 2007 - nature.com
… Paul J WoltersWolters, PJ et al. Tissue-selective mast cell reconstitution and differential
lung gene expression in mast cell-deficient Kit W-sh /Kit W-sh sash mice. Clin. … Paul J Wolters

Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis

…, CP Lydell, KD Jones, PJ Wolters… - American journal of …, 2011 - atsjournals.org
Rationale: Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic
pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the …

[HTML][HTML] Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

…, C Szekeres, MC Kugler, PJ Wolters… - The Journal of …, 2009 - Am Soc Clin Investig
Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant
wound healing and scarification. One population of fibroblasts involved in the fibrotic process is …