Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a global
public health threat. A significant challenge for TB control efforts has been the monitoring …

… The latter was reacted through an S N 2 reaction with phenol 2 e to afford ether 2 f.
Compound 2 f was treated with lithium iodide to selectively remove the methyl phosphonate …

Background Tuberculosis is the world's leading infectious disease killer. We aimed to
identify shorter, safer drug regimens for the treatment of tuberculosis. Methods We did a …

Up to now, publicly available data sets to build and evaluate Ames mutagenicity prediction
tools have been very limited in terms of size and chemical space covered. In this report we …

Rationale: Rifampin at a dose of 10 mg/kg was introduced in 1971 based on pharmacokinetic,
toxicity, and cost considerations. Available data in mice and humans showed that an …

Background A crucial impediment to global tuberculosis control is the lack of an accurate,
rapid diagnostic test for detection of patients with active TB. A new, rapid diagnostic method, (…

This study, focused on the laryngeal source level, introduces the concept of laryngeal vibratory
mechanism. Human phonation is characterized by the use of four laryngeal mechanisms, …

Background. Diagnosis and timely treatment of tuberculosis in children is hampered by the
absence of fast and reliable tests, especially in the era of human immunodeficiency virus (HIV…

… Norbert Heinrich … Heinrich N … Briefly, a maximum of 10 mL of sample was
homogenised and decontaminated with the N-acetyl-L-cysteine-sodium hydroxide procedure. …

The ligation of two polypeptides in a chemoselective manner by the bacterial transpeptidase
sortase A has become a versatile tool for protein engineering approaches. When sortase-…