Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho)…

… The Wood laboratory recently harnessed the RNA-transporting capacity of exosomes, providing
the first evidence for the delivery of exogenous siRNA using such vesicles 35 . Given the …

Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-…

Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …

The dwarf spheroidal satellite galaxies (dSphs) of the Milky Way are some of the most dark
matter (DM) dominated objects known. We report on γ-ray observations of Milky Way dSphs …

We have designed a modular protein tagging system that allows different functionalities to
be linked onto a single genetic fusion, either in solution, in living cells, or in chemically fixed …

We have measured the inclusive b→ s γ branching ratio to be (2.32±0.57±0.35)× 10− 4,
where the first error is statistical and the second is systematic. Upper and lower limits on the …

To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and
nonimmunogenic delivery technologies must be developed. Here we show that exosomes—endogenous …

… activity following exposure up to 8 M, whereas Fluc lost activity above 2 M. Both Nluc and
Fluc tolerated high concentrations of NaCl, but Nluc showed less inhibition at 10 M (Figure 3d). …

A fluorimetric microplate enzyme assay has been developed to study enzyme diversity in soil
as an approach to understanding functional diversity. The microplate assay allows a large …