The view of the endothelium as a passive barrier has gradually changed as a number of
endothelium-derived substances have been discovered. Substances like nitric oxide, …

Traumatic brain injury (TBI) is responsible for up to 45% of in-hospital trauma mortality. Computed
tomography (CT) is central to acute TBI diagnostics, and millions of brain CT scans are …

… admission represented by CT M grades 2–4 showed no significant difference in levels of
tissue damage markers compared with patients presenting more focal lesions (CT M grades 5–6…

Objective To evaluate the efficacy of early intracranial pressure (ICP)-targeted treatment,
compared to standard intensive care, in adults with community acquired acute bacterial …

Objective Levosimendan is a novel inodilator that improves cardiac contractility by sensitizing
troponin C to calcium. This drug has proved to be effective in treating advanced congestive …

High prevalence of thrombotic events in severely ill COVID-19 patients have been reported.
Pulmonary embolism as well as microembolization of vital organs may in these individuals …

Traumatic brain injury (TBI) is a major contributor to mortality and morbidity. The
pathophysiology involves development of brain edema. Therapeutic options are limited as the …

Erythropoietin (EPO) has neuroprotective effects in multiple central nervous system (CNS)
injury models; however EPO's effects on traumatic brain edema are elusive. To explore EPO …

Background Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients
with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical …

The COVID-19 pandemic highlighted the need for psychological support initiatives directed
toward frontline healthcare workers, which can be rapidly and sustainably implemented …