Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations
in blood to optimize pharmacotherapy. It considers the interindividual variability of …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

It is often challenging for the clinician interested in cystic fibrosis (CF) to interpret molecular
genetic results, and to integrate them in the diagnostic process. The limitations of genotyping …

Modern processors use branch prediction and speculative execution to maximize performance.
For example, if the destination of a branch depends on a memory value that is in the …

… Ratnam, and M. Wagner for discussions; three anonymous reviewers for comments on
the manuscript; M. García-Hernandez for help in managing co-author contributions; and A. …

… David McAdams and Schwarz (forthcoming) argue that in various settings, the costs … m). But
that implies that the advertiser assigned to position i cannot rematch profitably with position m…

… To aid in memory management, many modern operating systems directly map (a part of)
the physical memory in the kernel’s part of the virtual address space at a fixed location m (see …

Background The mutations that have been implicated in pulmonary fibrosis account for only
a small proportion of the population risk. Methods Using a genomewide linkage scan, we …

… The standard protocol for tree measurements in the field is to measure diameter at breast
height, defined as 1.3 m from the base of the stem. For non-cylindrical stems owing to …

This book provides a down-to-earth account of the virtues and failures of environmental risk
assessment. The assessment process involves politics, technology, and issues of social …