Many eukaryotic genes contain intervening sequences, segments of DNA that interrupt the
continuity of the gene. They are removed from RNA transcripts of the gene by a process …

A library of cloned cDNAs constructed from the poly(A)+RNA of the murine thymoma cell
line EL4 (b haplotype) was screened with a probe encoding a short region of the H-2Kb …

A mouse cDNA library derived from the EL4 cell line (b-haplotype) was screened with a
probe containing a small part of the H-2K b coding region. One of the clones isolated, pH203, …

… in 200 ml of 0.5 N NaOH, 0.15 M NaCl at room temperature for 30 min and then neutralized
with 200 ml of 0.05 M Tris-HCl pH 8.0, 0.15 M NaCl solution at room temperature for 20 min. …

Based on the published amino-acid sequence of H-2K b , we synthesized a mixture of eight
16-base long oligodeoxyribonucleotides representing all possible coding sequences for …

We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation,
exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase …

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions
and epigenetic modifications that drive malignant transformation. The Cancer Genome …

We performed an integrated genomic, transcriptomic and proteomic characterization of 373
endometrial carcinomas using array- and sequencing-based technologies. Uterine serous …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here, we …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …