[HTML][HTML] Structure-activity association of flavonoids in lung diseases

JHG Lago, AC Toledo-Arruda, M Mernak, KH Barrosa… - Molecules, 2014 - mdpi.com
Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones,
isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. …

[HTML][HTML] Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases

FPR Santana, NM Pinheiro, MIB Mernak… - Mediators of …, 2016 - hindawi.com
Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic
obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). …

Lung inflammation was attenuated by sakuranetin treatment in a model of acute lung injury

M Mernak, F Santana, N Pinheiro… - European …, 2014 - Eur Respiratory Soc
Acute lung injury (ALI) is characterized by diffuse inflammation and oxidative stress.
Sakuranetin (SK) is a flavonoid widely found in Baccharis retusa plant and presents anti-…

Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury

MI Bittencourt-Mernak, NM Pinheiro… - … of Physiology-Lung …, 2017 - journals.physiology.org
Sakuranetin is the main isolate flavonoid from Baccharis retusa (Asteraceae) leaves and
exhibits anti-inflammatory and antioxidative activities. Acute respiratory distress syndrome is an …

Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation

MI Bittencourt-Mernak, NM Pinheiro… - Journal of natural …, 2021 - ACS Publications
Acute lung injury (ALI) is an important public health problem. The present work investigated
whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant Nectandra …

Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation

…, FR Santana, M Bittencourt-Mernak… - European journal of …, 2020 - Elsevier
The cholinergic anti-inflammatory pathway has been shown to regulate lung inflammation
and cytokine release in acute models of inflammation, mainly via α7 nicotinic receptor (…

Vesicular acetylcholine transport deficiency potentiates some inflammatory responses induced by diesel exhaust particles

…, NM Pinheiro, MI Bittencourt-Mernak… - Ecotoxicology and …, 2019 - Elsevier
Endogenous acetylcholine (ACh), which depends of the levels of vesicular ACh transport (VAChT)
to be released, is the central mediator of the cholinergic anti-inflammatory system. …

Essential oils reduced lung inflammation in a model of acute lung injury

M Guerreiro, M Mernak, F Santana… - European …, 2014 - Eur Respiratory Soc
Acute respiratory distress syndrome is a high mortality clinical disorder characterized by lung
inflammation. Several monoterpenes from essential oils have an anti-inflammatory activity. …

[PDF][PDF] Galloyl-Hexahydroxydiphenoyl (HHDP)-Glucose Isolated From Punica granatum L

…, CM Prado, MI Bittencourt-Mernak… - … (LPS)-Induced Acute …, 2019 - academia.edu
… Reddy M, Gupta S, Jacob M, Khan S, Ferreira M. Antioxidant, antimalarial and antimicrobial
activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. …

Articles in PresS. Am J Physiol Lung Cell Mol Physiol (November 23, 2016). doi: 10.1152/ajplung. 00444.2015

MI Bittencourt-Mernak, NM Pinheiro, PR Fernanda… - 2016 - journals.physiology.org
Background and purpose. Sakuranetin is the main isolate flavonoid from Baccharis 42 retusa
(Asteraceae) leaves and exhibits anti-inflammatory and anti-oxidative activities. 43 Acute …