This work revises and complements existing findings on the distribution of drug‐metabolizing
enzymes in the first‐pass effect organs. We explored gene expression (quantitative …

Background Oxidative stress is heavily implicated in the pathogenic process of Parkinson's
disease. Varying capacity to detoxify radical oxygen species through induction of phase II …

Bioavailability of orally administered drugs is partly determined by function of drug
transporters in the liver and intestine. Therefore, we explored adenosine triphosphate–binding …

Objectives In this case–control study, we investigated the association of the most common
COMT gene haplotypes (formed by single nucleotide polymorphisms (SNPs): rs6269: A> G; …

The folate antagonist methotrexate (MTX) is a drug currently used in the treatment of
rheumatoid arthritis (RA). MTX enters the cells through the reduced folate carrier (RFC-1) and is …

Objective Eradication of Helicobacter pylori is an important treatment strategy in peptic ulcer
patients. Current regimens of eradication consist of proton pump inhibitor (PPI) and two …

Recent reports have proven the importance of genetic factors and inflammation in the
pathogenesis of sporadic Parkinson's disease (PD). In the current study, the frequency of CARD15/…

Objectives The study was aimed at evaluating the relationships between Hcy, vitamin B12,
and folic acid levels in the blood and cognitive status in PD patients with the genetic …

Allogenic solid organ transplantation has become the routine procedure in patients with end
stage organ disease. Although the transplanted organ compensates deficient body functions…

Objectives Pantoprazole is metabolized by cytochrome P450 2 C19, which shows genetic
polymorphism. The effect of CYP2C19 polymorphism on single-dose pharmacokinetics of oral …