Estimates suggest 8.5% of the UK adult population may have CKD stages 3-5 (Stevens, PE
et al, Kidney International 2007;72: 92-99), though this may be higher among COPD patients(…

The IL-17 pathway is an established driver of psoriasis pathogenesis. We examined the
detailed molecular and cellular effects of blockade of IL-17 signaling in human psoriatic skin …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity 1
. Herein we describe a new disease caused by high-penetrance heterozygous germline …

Background In psoriasis, only limited overlap between sets of genes identified as differentially
expressed (psoriatic lesional vs. psoriatic non-lesional) was found using statistical and fold…

Objectives The association between mutations in TNFAIP3, encoding the NF-kB regulatory
protein A20, and a new autoinflammatory disease has recently been recognised. This study …

… Three different buffer reagents were compared for this purpose: (I) 0.03 M ammonium
formate0.005 M MnSO,-o.oo5 M Tapazole (1-methyl-, 2-mercaptoimidazole) ; (2) 0. 9 % NaC10.05 …

In this chapter, we examine the role of text reading, reader interest, main idea, and “seductive
detail” in the learning of science and the development of scientific literacy. To orient the …

Objectives This study aimed to develop consensus on an internationally agreed dataset for
juvenile dermatomyositis (JDM), designed for clinical use, to enhance collaborative research …

The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia (CML)
patients after bone marrow transplantation. It was previously reported that the relapse …

Successful autologous hematopoietic stem cell (HSC) transplantation in childhood acute
lymphoblastic leukemia (ALL) requires the ability to either selectively kill the leukemia cells or …