Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients
Immunotherapy targeting the PD-L1/PD-1 axis has recently shown spectacular efficacy and
promise for the future of patients with metastatic lung cancer. In the setting of second-line …
promise for the future of patients with metastatic lung cancer. In the setting of second-line …
[HTML][HTML] Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues
Human papilloma viruses (HPV) are a small group of non‑enveloped viruses belonging to
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …
[HTML][HTML] Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma …
M Ilie, V Hofman, E Long, O Bordone… - Annals of …, 2014 - ncbi.nlm.nih.gov
The practice of “liquid biopsy” as a diagnostic, prognostic and theranostic tool in non-small
cell lung cancer (NSCLC) patients is an appealing approach, at least in theory, since it is …
cell lung cancer (NSCLC) patients is an appealing approach, at least in theory, since it is …
[HTML][HTML] Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a …
M Ilie, E Long-Mira, C Bence, C Butori, S Lassalle… - Annals of …, 2016 - Elsevier
Background High expression of programmed death ligand-1 (PD-L1) on tumor cells (TC)
and/or on tumor-infiltrating immune cells (IC) is associated with a high response rate in patients …
and/or on tumor-infiltrating immune cells (IC) is associated with a high response rate in patients …
[HTML][HTML] “Sentinel” circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease
M Ilie, V Hofman, E Long-Mira, E Selva, JM Vignaud… - PloS one, 2014 - journals.plos.org
Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer. Migration of
circulating tumor cells (CTCs) into the blood stream is an early event that occurs during …
circulating tumor cells (CTCs) into the blood stream is an early event that occurs during …
Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker
Purpose: Pathologic TNM staging is currently the best prognostic factor for non‐small cell
lung carcinoma (NSCLC). However, even in early-stage NSCLC, the recurrence rates after …
lung carcinoma (NSCLC). However, even in early-stage NSCLC, the recurrence rates after …
Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non‐small‐cell lung carcinoma: comparison of the efficacy of the …
V Hofman, MI Ilie, E Long, E Selva… - … journal of cancer, 2011 - Wiley Online Library
Abstract Comparison of the efficacy of different enrichment methods for detection of circulating
tumor cells (CTCs) before radical surgery is lacking in non‐small‐cell lung carcinoma (…
tumor cells (CTCs) before radical surgery is lacking in non‐small‐cell lung carcinoma (…
[HTML][HTML] Detection of PD-L1 in circulating tumor cells and white blood cells from patients with advanced non-small-cell lung cancer
M Ilié, E Szafer-Glusman, V Hofman, E Chamorey… - Annals of …, 2018 - Elsevier
Background Expression of PD-L1 in tumor cells and tumor-infiltrating immune cells has been
associated with improved efficacy to anti-PD-1/PD-L1 inhibitors in patients with advanced-…
associated with improved efficacy to anti-PD-1/PD-L1 inhibitors in patients with advanced-…
[HTML][HTML] High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer
Background: Carbonic anhydrase IX (CAIX) is an enzyme upregulated by hypoxia during
tumour development and progression. This study was conducted to assess if the expression of …
tumour development and progression. This study was conducted to assess if the expression of …
[HTML][HTML] ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma
M Ilie, E Long, C Butori, V Hofman, C Coelle, V Mauro… - Annals of oncology, 2012 - Elsevier
Background A subgroup of anaplastic lymphoma kinase (ALK)-rearranged lung tumours
can respond to ALK inhibitors. Until now, the ALK status in circulating tumour cells (CTCs) …
can respond to ALK inhibitors. Until now, the ALK status in circulating tumour cells (CTCs) …