Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations
as a major contributor to the development of insulin resistance and type 2 diabetes. In this …

Fat can be stored not only in adipose tissue but also in other tissues such as skeletal muscle.
Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be …

The uncoupling protein-1 (UCP1) homologues UCP2 and UCP3 are able to uncouple ATP
production from mitochondrial respiration, thereby dissipating energy as heat and affecting …

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function
and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate genes involved in energy metabolism and inflammation. For biological activity, PPARs …

In order to determine the ventilatory threshold (VT) and the lactate threshold (LT) in a
reliable way, a new method is proposed and compared with conventional methods. The new …

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT)
mass and activity. Here we report that 10 d of cold acclimation (14–15 C) increased …

… Muscles characterised by a high oxidative capacity (soleus) and a high glycolytic capacity
(extensor digitorum longus) were obtained from rats, while human m. vastus lateralis biopsies …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis
and the inflammatory response in macrophages. We show here that Rev-erb-α is highly …

OBJECTIVE Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased
intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes. We …