A complex and multilayered immune defence system protects the host against harmful
agents and maintains tissue homeostasis. Cigarette smoke ex posure markedly impacts the …

COPD is a complex syndrome that poses a serious health threat to >1.1 billion smokers
worldwide. The stable disease is punctuated by episodes of acute exacerbation, which are …

While the devastating impact of tobacco on human health is well established, and efforts to
reduce its prevalence are ongoing, over 1 billion people continue to smoke. Emerging …

The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin
(OVA) in the context of local expression of GM-CSF can initiate a Th2-driven, eosinophilic …

We investigated the impact of cigarette smoke exposure on respiratory immune defense
mechanisms. Mice were exposed to two cigarettes daily, 5 d/wk, for 2–4 mo. Tobacco smoke …

… Robbins CS, Dawe DE, Goncharova SI, Pouladi MA, Drannik AG, Swirski FK, Cox G, Stampfli
MR. Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune …

Background Cigarette smoking is the main risk factor for the development of chronic obstructive
pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite …

Selective accumulation of eosinophils and activated CD4+ cells is now considered a central
event in the pathogenesis of asthma, and this process is thought to be mediated by a …

NK cells play essential roles in innate host defense against microbial infections and tumor
surveillance. Although evidence suggests that smoking has adverse effects on the immune …

The objective of this study was to characterize the impact of cigarette smoke exposure on
lung immune and inflammatory processes. BALB/c and C57BL/6 mice were exposed to …