Rapid demographic, sociocultural, and economic transitions are driving increases in the risk
and prevalence of diabetes and other non-communicable diseases (NCDs) in sub-Saharan …

Glucocorticoids, 11β-hydroxysteroid dehydrogenase, and fetal programming. Epidemiological
studies in many distinct human populations have associated low weight or thinness at …

Compelling epidemiological evidence suggests that exposure to an adverse intrauterine
environment, manifested by low-birth weight, is associated with cardiometabolic and …

Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The
molecular mechanisms underlying this link are unknown but fetal exposure to excess …

Background Tackling severe acute malnutrition (SAM) is a global health priority. Heightened
risk of non-communicable diseases (NCD) in children exposed to SAM at around 2 years of …

Liver fat accumulation is proposed to link obesity and insulin resistance. To dissect the role
of liver fat in the insulin resistance of diet-induced obesity, we altered liver fat using a choline-…

Hyperkalaemia is defined as serum potassium concentration greater than 5.5 mmol/l. Its
prevalence in the general population is unknown, but it is thought to occur in 1-10% of patients …

In a previous study, we showed that exposure of rats to dexamethasone (Dex) selectively in
late pregnancy produces permanent induction of hepatic phosphoenolpyruvate …

Sub-Saharan Africa is experiencing a rapidly increasing epidemic of non-communicable
diseases (NCDs), while it continues to face longstanding challenges from infectious diseases. …

Background Hypertension and diabetes prevalence is high in Africans. Data from HIV
infected populations are limited, especially from Malawi. Integrating care for chronic non-…