Atopic dermatitis (AD) is a chronic itching (pruritic) skin disease. It results from a complex
interplay between strong genetic and environmental factors. Genome screens of families with …

Molecular techniques have revolutionized the practice of standard microbiology. In particular,
16S rRNA sequencing, whole microbial genome sequencing and metagenomics are …

The Human Microbiome Project began 10 years ago, leading to a significant growth in
understanding of the role the human microbiome plays in health and disease. In this article, we …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Background The study of microbial communities has been revolutionised in recent years by
the widespread adoption of culture independent analytical techniques such as 16S rRNA …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Asthma is caused by a combination of poorly understood genetic and environmental factors
1 , 2 . We have systematically mapped the effects of single nucleotide polymorphisms (SNPs…

Background A rich microbial environment in infancy protects against asthma [1] , [2] and
infections precipitate asthma exacerbations [3] . We compared the airway microbiota at three …

We have created a global map of the effects of polymorphism on gene expression in 400
children from families recruited through a proband with asthma. We genotyped 408,273 SNPs …