User profiles for M. D. Lougheed

M Diane Lougheed

Professor of Medicine, Queen's University
Verified email at queensu.ca
Cited by 5071

[HTML][HTML] Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment

JD Brannan, MD Lougheed - Frontiers in physiology, 2012 - frontiersin.org
Airway hyperresponsiveness (AHR) and airway inflammation are key pathophysiological
features of asthma. Bronchial provocation tests (BPTs) are objective tests for AHR that are …

Nylon flock–associated interstitial lung disease

WL Eschenbacher, K Kreiss, MD Lougheed… - American journal of …, 1999 - atsjournals.org
Lougheed and coworkers (1) conjectured that the lung disease process in these workers
represented a response to a toxic inhalational injury. Subsequent to publication of this report, …

Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults

MD Lougheed, C Lemiere, FM Ducharme… - Canadian respiratory …, 2012 - hindawi.com
… In contrast, in the pediatric studies, there was a significant increase in ICS dose in the FeNO
strategy arm (MD 140 mcg [95% CI 29 mcg to 251 mcg], budesonide equivalent/day). Thus, …

Effect of outdoor particulate air pollution on FEV1 in healthy adults: a systematic review and meta-analysis

…, DE O'Sullivan, W King, MD Lougheed - Occupational and …, 2019 - oem.bmj.com
The effect of acute and long-term exposures to outdoor particulate air pollution on lung
function in healthy adults is not well established. The objective of this study was to conduct a …

Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis

…, A Freitag, N Paterson, M Jackson, MD Lougheed… - Thorax, 2011 - thorax.bmj.com
Background Despite advances in treatment of cystic fibrosis (CF), pulmonary exacerbations
remain common. The aim of this study was to determine if frequent pulmonary exacerbations …

Canadian Thoracic Society Asthma Management Continuum–2010 Consensus Summary for children six years of age and over, and adults

MD Lougheed, C Lemière, SD Dell… - Canadian respiratory …, 2010 - hindawi.com
BACKGROUND/OBJECTIVE: To integrate new evidence into the Canadian Asthma Management
Continuum diagram, encompassing both pediatric and adult asthma.METHODS: The …

Increasing incidence and prevalence of World Health Organization groups 1 to 4 pulmonary hypertension: a population-based cohort study in Ontario, Canada

…, K Lajkosz, SB Brogly, MD Lougheed… - … Quality and Outcomes, 2018 - Am Heart Assoc
Background: The World Health Organization recognizes 5 groups of pulmonary hypertension
(PH), categorized by pathogenesis or comorbidity: 1-pulmonary arterial hypertension 2-left-…

Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis

…, A Freitag, N Paterson, M Jackson, MD Lougheed… - Jama, 2010 - jamanetwork.com
Context Studies from Australia and the United Kingdom have shown that some patients with
cystic fibrosis are infected with common transmissible strains of Pseudomonas aeruginosa. …

Progression from asthma to chronic obstructive pulmonary disease. Is air pollution a risk factor?

…, K Ryckman, A Gershon, MD Lougheed… - American journal of …, 2016 - atsjournals.org
Rationale: Individuals with asthma–chronic obstructive pulmonary disease (COPD) overlap
syndrome (ACOS), have more rapid decline in lung function, more frequent exacerbations, …

Breathlessness during acute bronchoconstriction in asthma: pathophysiologic mechanisms

MD Lougheed, MIU Lam, L Forkert… - American Review of …, 1993 - atsjournals.org
The purpose of this study was to examine potential contributing factors to breathlessness
during bronchoconstriction, in particular, to evaluate the role of lung hyperinflation. We also …