Background We present the combined results of two trials that compared adjuvant
chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-…

… Interphase cells contain a single centrosome that is typically located near the nucleus and
contains of a pair of centrioles that anchor the recruitment of pericentriolar material including …

Objective Supervised exercise programs (SEP) are effective for improving walking distance
in patients with intermittent claudication (IC) but provision and uptake rates are suboptimal. …

Cardiac rehabilitation is a package of lifestyle secondary prevention strategies designed for
patients with coronary heart disease and chronic heart failure. A community-based cardiac …

Purpose Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of
tamoxifen metabolites, but their effect on clinical outcome is unknown. Methods We …

Background Tamoxifen is biotransformed to the potent anti-estrogen, endoxifen, by the
cytochrome P450 (CYP) 2D6 enzyme. CYP2D6 genetic variation and inhibitors of the enzyme …

The centrosome plays an important role in maintenance of cell polarity and in progression
through the cell cycle by determining the number, polarity, and organization of interphase and …

… A series of single- and multi-joint upper and lower body exercises was incorporated into the
resistance training component of the programme. The progression characteristics ( Table I ) …

Purpose To evaluate concordance between local and central laboratory HER2 testing results
in patients from the North Central Cancer Treatment Group (NCCTG) N9831 adjuvant trial …

Aims The 6-min walk test (6-MWT) is used to estimate functional capacity. However, in
elderly patients with chronic heart failure (CHF): (i) 1 year reproducibility of the 6-MWT; (ii) …