Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders

LW Brüggemann, HH Versteeg… - Journal of cellular …, 2008 - Wiley Online Library
… - Brüggemann - 2008 - Journal of Cellular and Molecular Medicine - Wiley Online Library …
supported by grants from the Netherlands Heart Foundation to LW Brüggemann (99.197). …

Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer

LW Brüggemann, KCS Queiroz, K Zamani… - Cancer biology & …, 2010 - Taylor & Francis
The developmental Hedgehog (Hh) pathway has been shown to cause malignancies in the
adult organism, specifically in the proximal gastrointestinal tract. Previous studies have used …

[HTML][HTML] Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung

TMH Niers, LW Brüggemann, CPW Klerk… - Clinical & experimental …, 2009 - Springer
Cancer progression is facilitated by blood coagulation. Anticoagulants, such as Hirudin and
low molecular weight heparins (LMWHs), reduce metastasis mainly by inhibition of thrombin …

[HTML][HTML] Smoothened-dependent and-independent pathways in mammalian noncanonical Hedgehog signaling

AVS Faria, AI Akyala, K Parikh, LW Brüggemann… - Journal of Biological …, 2019 - ASBMB
Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving
first activation of ligand binding to Patched followed by alleviation of Smoothened receptor …

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

…, MF Bijlsma, AP Groot, LW Brüggemann… - Experimental cell …, 2007 - Elsevier
Coagulation Factor (F)Xa is a serine protease that plays a crucial role during blood
coagulation by converting prothrombin into active thrombin. Recently, however, it emerged that …

Long‐term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis

TMH Niers, LW Brüggemann, GL Van Sluis… - Journal of Thrombosis …, 2009 - jthjournal.org
The association between cancer and venous thromboembolism (VTE) is mostly considered
to be unidirectional. However, recent data show that the development of VTE leads to a …

Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice

LW Brüggemann, SHHF Schoenmakers… - Critical care …, 2006 - journals.lww.com
Brüggemann and Saskia HHF Schoenmakers contributed equally to this manuscript. …
Schoenmakers SH, Brüggemann LW, Groot AP, et al: Role of coagulation FVIII in septic peritonitis …

[BOOK][B] “A” View of the English Editions, Translations and Illustrations of the Ancient Greek and Latin Authors, with Remarks

LW Brüggemann - 1797 - books.google.com
Claffical cal learning has no doubt found its firſt and principal promotors in Italy, France,

Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation

GL Van Sluis, LW Brüggemann, CT Esmon… - Cancer letters, 2011 - Elsevier
Fibrinogen and platelets play an important role in cancer cell survival in the circulation by
protecting cancer cells from the immune system. Moreover, endogenous activated protein C (…