The treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant
(MDR) or extensively drug-resistant (XDR) pathogens and lack of development of …

We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae
by using studies from around the world published before April 9, 2012. Attributable death …

… coli and K. pneumoniae were the most frequently studied pathogens. … coli or K. pneumoniae
were too limited to allow for meaningful comparisons as the authors either studied a small …

BACKGROUND: Candidemia is among the leading causes of nosocomial bloodstream
infections and is associated with significant mortality. Several centers have published data …

Sex is a significant epidemiological factor for several diseases. However, the role of sex in
the development and outcome of various infections has not been extensively studied with the …

We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD)
properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, …

The objective of this review was to evaluate the frequency of treatment failure and recurrence
of Clostridium difficile infection (CDI) following treatment with vancomycin or metronidazole …

Background The findings of randomised controlled trials (RCT), observational studies, and
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …

Background . The addition of an aminoglycoside to a β-lactam therapy regimen has been
suggested to have a beneficial effect in delaying or preventing the development of …

Linezolid has been approved for the treatment of patients with infections caused by Gram-positive
cocci that are resistant to traditionally used antibiotics, including glycopeptides. This …