In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation
from precursor cells, prevented osteoporosis (decreased bone mass) when administered to …

… Eppen dahl & KT Preissner, unpublished data), arterial smooth muscle cells (J. Rupp & KT
Preissner, unpublished observation), or glioblastoma cells (Gladson et al 1990) are described …

… Bronson RA, Preissner KT. Measurement of vitronectin content of human spermatozoa and
… Hammes HP, Weiss A, Hess S, Araki N, Horiuchi S, Brownlee M, Preissner KT. Modification …

Deep vein thrombosis (DVT) is a major cause of cardiovascular death. The sequence of
events that promote DVT remains obscure, largely as a result of the lack of an appropriate …

Neutrophils play an important role in innate immunity by defending the host organism against
invading microorganisms. Antimicrobial activity of neutrophils is mediated by release of …

Blood neutrophils provide the first line of defense against pathogens but have also been
implicated in thrombotic processes. This dual function of neutrophils could reflect an …

The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine
kinase Tie-2 (refs. 1 , 2 ). Paracrine Ang-1–mediated activation of Tie-2 acts as a regulator of …

Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce
angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome–…

The pattern recognition receptor, RAGE (receptor for advanced glycation endproducts),
propagates cellular dysfunction in several inflammatory disorders and diabetes. Here we show …

Upon vascular injury, locally controlled haemostasis prevents life-threatening blood loss and
ensures wound healing. Intracellular material derived from damaged cells at these sites will …