In pulmonary sarcoidosis, CD4 + T-cells expressing T-cell receptor Vα2.3 accumulate in the
lungs of HLA-DRB1*03 + patients. To investigate T-cell receptor-HLA-DRB1*03 interactions …

Background: Female Elkhounds are shown to be at increased risk for diabetes mellitus, and
occurrence of diabetes during pregnancy has been described in several cases. Hypothesis: …

Epoxide hydrolases catalyze the conversion of epoxides to diols. The known functions of
such enzymes include detoxification of xenobiotics, drug metabolism, synthesis of signaling …

Background Autoimmune disease is one of the leading causes of morbidity and mortality
worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. …

Aims/Hypothesis Diabetes mellitus is one of the most common endocrine disorders in dogs
and is commonly proposed to be of autoimmune origin. Although the clinical presentation of …

EAE , an animal model for multiple sclerosis, is a T h17‐ and T h1‐cell‐mediated auto‐immune
disease, but the mechanisms leading to priming of encephalitogenic T cells in …

Increased IL‐17A secretion in response to Candida albicans in autoimmune polyendocrine
syndrome type 1 and its animal model - Ahlgren - 2011 - European Journal of Immunology - …

Objective Copy number variation of the C4 complement components, C4A and C4B, has been
associated with systemic inflammatory autoimmune diseases. This study was undertaken …

Background In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are
associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity…

Autoantibodies against interleukin (IL)‐17A, IL‐17F and IL‐22 have recently been described
in patients with autoimmune polyendocrine syndrome type I (APS I), and their presence is …