Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors

KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …

Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations

KL Becker, R Snider, ES Nylen - Critical care medicine, 2008 - journals.lww.com
Objective: The use of procalcitonin (ProCT) as a marker of several clinical conditions, in
particular, systemic inflammation, infection, and sepsis, will be clarified, and its current limitations …

Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target

KL Becker, R Snider, ES Nylen - British journal of …, 2010 - Wiley Online Library
The worldwide yearly mortality from sepsis is substantial, greater than that of cancer of the
lung and breast combined. Moreover, its incidence is increasing, and its response to therapy …

Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit

B Müller, KL Becker, H Schächinger… - Critical care …, 2000 - journals.lww.com
… Snider RH, Nylen ES, Becker KL: Procalcitonin and its component peptides in systemic
inflammation: Immunochemical characterization. J Invest Med 1997; 45:552-560 33. Zweig MH, …

Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis

…, ES Nylén, RH Snider, KL Becker… - The Journal of …, 2001 - academic.oup.com
Calcitonin precursors (CTpr), including procalcitonin, are important markers and also potentially
harmful mediators in response to microbial infections. The source and function of CTpr …

[BOOK][B] Principles and practice of endocrinology and metabolism

KL Becker - 2001 - books.google.com
Established as the foremost text in the field, Principles and Practice of Endocrinology and
Metabolism is now in its thoroughly revised, updated Third Edition. This practical, clinically …

In Vitro and in Vivo Calcitonin I Gene Expression in Parenchymal Cells: A Novel Product of Human Adipose Tissue

…, ES Nylen, I Langer, M Schlatter, KL Becker… - …, 2003 - academic.oup.com
Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase
up to several thousand-fold in human sepsis, and immunoneutralization improves survival in …

Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis

…, PM Steinwald, JC White, KL Becker - Critical care …, 1998 - journals.lww.com
Objectives Procalcitonin (ProCT), the precursor to the calcitonin hormone, is abnormally
increased in experimental and clinical systemic inflammation, including sepsis. Initially, we …

[HTML][HTML] Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

…, KS Polonsky, D Ostrega, KL Becker… - The Journal of …, 2003 - Am Soc Clin Investig
We have previously described the only reported case of human proprotein convertase 1 (PC1)
deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and …

Serum calcitonin precursors in sepsis and systemic inflammation

…, GL Simon, RL Goldberg, KL Becker - The Journal of …, 1998 - academic.oup.com
High serum levels of the calcitonin (CT) prohormone, procalcitonin (pro-CT), and its
component peptides occur in systemic inflammation and sepsis. Using two different assays, we …
In response to a complaint we received under the US Digital Millennium Copyright Act, we have removed 1 result(s) from this page. If you wish, you may read the DMCA complaint that caused the removal(s) at LumenDatabase.org.