N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

KA Cadwallader, H Paterson… - … and cellular biology, 1994 - Am Soc Microbiol
Plasma membrane targeting of Ras requires CAAX motif modifications together with a
second signal from an adjacent polybasic domain or nearby cysteine palmitoylation sites. N-…

Polymers of α1-Antitrypsin Are Chemotactic for Human Neutrophils: A New Paradigm for the Pathogenesis of Emphysema

…, BJ Reed, N Farahi, KA Cadwallader… - American journal of …, 2002 - atsjournals.org
Plasma deficiency of α 1 -antitrypsin is most commonly due to the Z mutation ( 342 Glu →
Lys) and is associated with early-onset panlobular emphysema. The lung disease in these …

Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of 18F-FDG PET images

HA Jones, KA Cadwallader, JF White… - Journal of Nuclear …, 2002 - Soc Nuclear Med
Neutrophil granulocytes play a key role in the pathogenesis of a wide variety of pulmonary
diseases. In many such conditions, the injury observed reflects the activation status rather …

Role of PI3-kinase–dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival

AS Cowburn, KA Cadwallader, BJ Reed… - Blood, The Journal …, 2002 - ashpublications.org
Phosphoinositide 3-kinase (PI3-kinase)–dependent phosphorylation of the proapoptotic Bcl-2
family member Bad has been proposed as an important regulator of apoptotic cell death. …

[HTML][HTML] Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal …

SJ Cook, J Beltman, KA Cadwallader… - Journal of Biological …, 1997 - ASBMB
Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF)
results in a biphasic, sustained activation of extracellular signal-regulated kinase 1 (ERK1). …

The role of HIF-1α in myeloid cell inflammation

SR Walmsley, KA Cadwallader, ER Chilvers - Trends in immunology, 2005 - cell.com
Myeloid cells are key effectors of the innate immune response, and as such are often required
to migrate to, and function within, sites that are markedly hypoxic. To adapt to such oxygen …

Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation

DJ McKeon, KA Cadwallader, S Idris… - European …, 2010 - Eur Respiratory Soc
Previous studies have identified abnormalities in the oxidative responses of the neutrophil in
cystic fibrosis (CF), but it is unclear whether such changes relate to loss of membrane cystic …

The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention

ER Chilvers, KA Cadwallader, BJ Reed… - Journal of the Royal …, 2000 - ncbi.nlm.nih.gov
Neutrophils play a key role in the immediate non specific immune response, and defects in
their function increase host susceptibility to a range of infective agents. However, excess …

Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3, 4, 5-trisphosphate accumulation by neutrophil priming agents

KA Cadwallader, AM Condliffe, A McGregor… - The Journal of …, 2002 - journals.aai.org
Neutrophil priming by agents such as TNF-α and GM-CSF causes a dramatic increase in the
response of these cells to secretagogue agonists and affects the capacity of neutrophils to …

[HTML][HTML] Aminopeptidase N (CD13) regulates tumor necrosis factor-α-induced apoptosis in human neutrophils

…, J Deighton, J Murray, KA Cadwallader… - Journal of biological …, 2006 - ASBMB
Neutrophil apoptosis plays a central role in the resolution of granulocytic inflammation. We
have shown previously that tumor necrosis factor-α (TNFα) enhances the rate of neutrophil …