[HTML][HTML] Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

FN Schleich, M Manise, J Sele, M Henket… - BMC pulmonary …, 2013 - Springer
Background Phenotyping asthma according to airway inflammation allows identification of
responders to targeted therapy. Induced sputum is technically demanding. We aimed to …

Exhaled nitric oxide thresholds associated with a sputum eosinophil count≥ 3% in a cohort of unselected patients with asthma

FN Schleich, L Seidel, J Sele, M Manise, V Quaedvlieg… - Thorax, 2010 - thorax.bmj.com
Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a
surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO …

Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease

C Moermans, V Heinen, M Nguyen, M Henket, J Sele… - Cytokine, 2011 - Elsevier
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway
inflammatory disease caused by repeated exposure to noxious gases or particles. It is now …

Sputum eosinophil count in a large population of patients with mild to moderate steroid‐naive asthma: distribution and relationship with methacholine bronchial …

R Louis, J Sele, M Henket, D Cataldo, J Bettiol… - Allergy, 2002 - Wiley Online Library
Background: Although airway eosinophilia is seen as a cardinal feature of asthma, data
eosinophilia are still lacking on the proportion of the asthma group exhibiting raised airway …

Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross‐sectional study in daily practice

V Quaedvlieg, J Sele, M Henket… - Clinical & Experimental …, 2009 - Wiley Online Library
Background The primary end‐point in the management of asthma is to obtain optimal control.
The aim of this study was to assess the relationships between the markers of airway …

Leukotriene B4 contributes to exhaled breath condensate and sputum neutrophil chemotaxis in COPD

JL Corhay, M Henket, D Nguyen, B Duysinx, J Sele… - Chest, 2009 - Elsevier
… Nguyen MD a , Bernard Duysinx MD, PhD a , Jocelyne Sele a b , Renaud Louis MD, PhD
a … Sele conducted all of the in vitro analyses. Drs. Duysinx and Nguyen recruited COPD …

Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease

…, D Cataldo, MG Buckley, J Sele… - European …, 2002 - Eur Respiratory Soc
Although asthma has been viewed mainly as an eosinophilic disease, and chronic
obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown …

Cytokine production from sputum cells after allergenic challenge in IgE‐mediated asthma

J Bettiol, J Sele, M Henket, E Louis, M Malaise… - Allergy, 2002 - Wiley Online Library
Background: Th2 cytokine production from airway cells is thought to govern the eosinophilic
airways inflammation in allergic asthma. Induced sputum has become a widely used …

Is FENO50 useful diagnostic tool in suspected asthma?

…, R Asandei, M Manise, J Sele… - … journal of clinical …, 2012 - Wiley Online Library
Background: Asthma diagnosis is based on the presence of symptoms and the demonstration
of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, …

Granulocyte chemotactic activity in exhaled breath condensate of healthy subjects and patients with COPD

JL Corhay, L Hemelaers, M Henket, J Sele, R Louis - Chest, 2007 - Elsevier
Background Several chemoattractants have been measured in exhaled breath condensate (EBC)
from patients with COPD. The aim of this study was to compare the eosinophil and …