[HTML][HTML] Asthma and obesity: two diseases on the rise and bridged by inflammation

M Bantulà, J Roca-Ferrer, E Arismendi… - Journal of clinical …, 2021 - mdpi.com
Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent, causal, …

Expression of glucocorticoid receptor α-and β-isoforms in human cells and tissues

L Pujols, J Mullol, J Roca-Ferrer… - … of Physiology-Cell …, 2002 - journals.physiology.org
Alternative splicing of the human glucocorticoid receptor (GR) primary transcript generates
two protein isoforms: GR-α and GR-β. We investigated the expression of both GR isoforms in …

Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics

…, M Juan, J Roca-Ferrer… - American Journal of …, 1999 - atsjournals.org
Exogenous prostaglandin E 2 (PGE 2 ) given by inhalation almost completely abrogates
aspirin-induced asthma and the accompanying increase in cysteinyl-leukotrienes production. …

[HTML][HTML] Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity

L Machado-Carvalho, J Roca-Ferrer, C Picado - Respiratory research, 2014 - Springer
Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist and are
always present in patients with aspirin exacerbated respiratory disease (AERD). Although the …

Reduced expression of COXs and production of prostaglandin E2 in patients with nasal polyps with or without aspirin-intolerant asthma

J Roca-Ferrer, FJ Garcia-Garcia, J Pereda… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Researchers have debated whether regulation of the COX enzymes (COX-1
and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis …

Mucin genes have different expression patterns in healthy and diseased upper airway mucosa

…, C Debolos, M Garrido, J RocaFerrer… - Clinical & …, 2006 - Wiley Online Library
Background Mucus hyper‐secretion is a feature of several airways diseases such as chronic
rhinosinusitis, asthma, and cystic fibrosis (CF). Since mucins are major components of …

Expression of the human glucocorticoid receptor α and β isoforms in human respiratory epithelial cells and their regulation by dexamethasone

L Pujols, J Mullol, M Pérez, J Roca-Ferrer… - American journal of …, 2001 - atsjournals.org
Two isoforms of the human glucocorticoid receptor (hGR) have been described, hGR α and
hGR β . We analyzed the expression and regulation of both hGR isoforms in human …

Role of microRNAs in inflammatory upper airway diseases

…, J RocaFerrer, C Marin, Z Liu, DY Wang, J Mullol - Allergy, 2021 - Wiley Online Library
MicroRNAs (miRNAs) are a conserved family of small endogenous noncoding RNA molecules
that modulate post‐transcriptional gene expression in physiological and pathological …

Cytokine gene expression and release from epithelial cells. A comparison study between healthy nasal mucosa and nasal polyps

…, A Xaubet, A Gaya, J RocaFerrer… - Clinical & …, 1995 - Wiley Online Library
… Dr J. Mullol was supported in part by grants from Fundacio Catalana de Pneumologia and
from … Roca-Ferrer and JC Fernandez were supported in part by grants from Fundacio Privada …

Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis.

…, S Cardelus, P Benitez, JM Guilemany, J Roca-Ferrer… - Rhinology, 2011 - europepmc.org
Background Loss of sense of smell is one of the most frequent complaints in patients with
nasal polyposis (NP). The aim of this study was to evaluate the impact of asthma and its …