Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects independently, …

Background Previous studies have suggested that exercise training improves cardiac
autonomic drive in young and middle-aged adults. In this study, we discuss the benefits for the …

DNA polymerases carry out DNA synthesis during DNA replication, DNA recombination and
DNA repair. During the past five years, the number of DNA polymerases in both eukarya …

While protein or enzyme immobilization methodologies are readily applicable in a majority
of industrial processes, some lacunas still remain. For example, the multi‐step, wet‐chemical …

Cytos 2 experiment, carried out during the French-Soviet manned flight (July 1982), has studied
the antibiotics sensitivity of bacteria cultivated in vitro during the orbital flight. The results …

The complete genome sequence of the hyperthermophilic archaeon Pyrococcus abyssi
revealed the presence of a family B DNA polymerase (Pol I) and a family D DNA polymerase (…

Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood
biomarkers of neurodegeneration remains poorly investigated. We explored the cross-…

Background No study has tried to distinguish subjects that become frail due to diseases (frailty
related to diseases) or in the absence of specific medical events; in this latter case, it is …

Aim Mitochondrial dysfunction is associated with the development of type 2 diabetes
mellitus (T2DM). It is thus of clinical relevance to identify plasma biomarkers of mitochondrial …