SummaryThe mRNA-based BNT162b2 vaccine from Pfizer/BioNTech was the first registered
COVID-19 vaccine and has been shown to be up to 95% effective in preventing SARS-CoV-…

Dysregulation of inflammation is hypothesized to play a crucial role in the severe complications
of COVID-19, with the IL-1/IL-6 pathway being central. Here, we report on the treatment …

Importance Although inadequate sleep has a proven negative association with health care
outcomes, to date, no large-scale studies have examined sleep in general hospital wards. …

Background Knowledge on bacterial co-infections in COVID-19 is crucial to use antibiotics
appropriately. Therefore, we aimed to determine the incidence of bacterial co-infections, …

Purpose Patients with sepsis—after surviving the initial hyperinflammatory phase—display
features consistent with immunosuppression, including hyporesponsiveness of …

Objective To describe clinical characteristics, disease course and outcomes in a large and
well-documented cohort of hospitalized COVID-19 patients in the Netherlands. Methods We …

Rationale: Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs)
is considered to be important for an appropriate immune response against pathogens …

The clinical spectrum of COVID-19 varies and the differences in host response characterizing
this variation have not been fully elucidated. COVID-19 disease severity correlates with an …

Background Previous studies have reported on myocardial injury in patients with coronavirus
infectious disease 19 (COVID-19) defined as elevated cardiac biomarkers. Whether …

Background Emergency departments (EDs) are the entrance gates for patients presenting
with infectious diseases into the hospital, yet most antimicrobial stewardship programmes are …