The DNA damage response (DDR), through the action of sensors, transducers, and effectors,
orchestrates the appropriate repair of DNA damage and resolution of DNA replication …

Acne is one of the most common disorders treated by dermatologists and other health care
providers. While it most often affects adolescents, it is not uncommon in adults and can also …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms. Moreover…

Among the earliest and most important stages during tumorigenesis is the activation of the
angiogenic process, an event that is termed the “switch to the angiogenic phenotype.” We …

… JAMES HARPER, the grandfather of the four brothers who founded the house of … At the
same time that Joseph Harper was pecuniarily assisting the young firm of J. & J. …

The cyclin-dependent kinase CdkP associates with cyclins A, D, and E and has been
implicated in the control of the Gl to S phase transition in mammals. To identify potential Cdk2 …

The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …

The first chapter is concerned with experiments, analogies and models. There are sections
on dispersal, dormancy and recruitment of seedling populations, effects of neighbours, effects …

This text book presents an integrated study of plant and animal ecology with mathematical
and laboratory studies described where necessary. Examples drawn from real ecological …

p21 CIP11WAF1 is a CDK Inhibitor regulated by the tumor suppressor p53 and is hypothesized
to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from …