Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine
lung tumors. Here we provide an overview of the most updated data on the molecular …

Diagnosing a pulmonary neuroendocrine neoplasm (NEN) may be difficult, challenging
clinical decision making. In this review key clinical and pathological issues and informative …

Purpose: Previous genomic studies have identified two mutually exclusive molecular subtypes
of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly comutated …

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an orphan disease and few
data are available on its clinical characteristics. Therefore, we analysed LCNEC registered in …

Objectives Pulmonary neuroendocrine neoplasms (NENs) are subdivided in carcinoids and
neuroendocrine carcinomas (small cell lung carcinoma and large cell neuroendocrine …

… Derks and R. van Sulyen prior to the central review meetings. The assessors evaluated …
Derks). LCNEC was established when at least two pathologists agreed on the diagnosis, …

Objectives Biological predisposition for specific metastatic organs might differ between
molecular subgroups of lung cancer. We aimed to assess the association between molecular …

Purpose To analyse the prognostic impact on overall survival (OS) of single versus multiple
organ metastases, organ affected, and local disease status in a population based stage IV …

… Author links open overlay panel BCM Hermans a , JL Derks a , E. Thunnissen b , RJ van
Suylen c , MA den Bakker d e , HJM Groen f , EF Smit g , RA Damhuis h , EC van den Broek i , …

Aims Pulmonary large cell neuroendocrine carcinoma ( LCNEC ) is underdiagnosed on biopsy
specimens. We evaluated if routine neuroendocrine immunohistochemical ( IHC ) stains …