User profiles for J. K. Burgess
Janette BurgessGroningen Research Institute for Asthma and COPD, University Medical Center Groningen Verified email at umcg.nl Cited by 11248 |
Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
The extracellular matrix–the under‐recognized element in lung disease?
The lung is composed of airways and lung parenchyma, and the extracellular matrix ( ECM )
contains the main building blocks of both components. The ECM provides physical support …
contains the main building blocks of both components. The ECM provides physical support …
The human lung cell atlas: a high-resolution reference map of the human lung in health and disease
…, GRS Budinger, JK Burgess… - American journal of …, 2019 - atsjournals.org
Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung
cell types in health and disease is currently revolutionizing the identification of disease …
cell types in health and disease is currently revolutionizing the identification of disease …
Airway smooth muscle cell proliferation is increased in asthma
…, M Hughes, QI Ge, G King, JK Burgess… - American journal of …, 2001 - atsjournals.org
Increased airway smooth muscle (ASM) within the bronchial wall of asthmatic patients has
been well documented and is likely to be the result of increased muscle proliferation. We have …
been well documented and is likely to be the result of increased muscle proliferation. We have …
Interaction between glucocorticoids and β2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling
…, PRA Johnson, JJ Rüdiger, GG King, Q Ge, JK Burgess… - The Lancet, 2002 - thelancet.com
Background Increased airway smooth muscle bulk is a pathological feature of asthma.
Asthma is well controlled by the combined inhalation of glucocorticoids and β 2 -adrenoceptor …
Asthma is well controlled by the combined inhalation of glucocorticoids and β 2 -adrenoceptor …
[HTML][HTML] Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
…, GG King, Q Ge, K Hostettler, JK Burgess… - … England Journal of …, 2004 - Mass Medical Soc
Background Increased proliferation of bronchial smooth-muscle cells may lead to increased
muscle mass in the airways of patients with asthma. The antiproliferative effect of …
muscle mass in the airways of patients with asthma. The antiproliferative effect of …
Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism
PRA Johnson, JK Burgess, PA Underwood… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: Airway remodeling is a key feature of persistent asthma and includes
alterations in the extracellular matrix protein profile around the airway smooth muscle (ASM) and …
alterations in the extracellular matrix protein profile around the airway smooth muscle (ASM) and …
[HTML][HTML] The processes and mechanisms of cardiac and pulmonary fibrosis
…, SA Hardy, DW Waters, JK Burgess… - Frontiers in …, 2017 - frontiersin.org
Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized
by the accumulation of extracellular matrix components, particularly collagen, at the site of …
by the accumulation of extracellular matrix components, particularly collagen, at the site of …
Treating asthma means treating airway smooth muscle cells
…, A Fust, S Dhaliwal, JK Burgess - European …, 2008 - Eur Respiratory Soc
Asthma is characterised by airway hyperresponsiveness, airway inflammation and airway
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway …
remodelling. Airway smooth muscle cells are known to be the main effector cells of airway …
Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages
Background: Rhinovirus infection is responsible for considerable morbidity and mortality as
the major cause of exacerbations of asthma, and is also known to induce exacerbations of …
the major cause of exacerbations of asthma, and is also known to induce exacerbations of …