[HTML][HTML] Cell receptors and cell signalling

IJ Uings, SN Farrow - Molecular Pathology, 2000 - ncbi.nlm.nih.gov
All cells in a multicellular organism are constantly exposed to a variety of extracellular signals
that they need to interpret and translate into an appropriate response to their environment. …

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

…, AM Riou, P Homes, SL Martin, IJ Uings… - Journal of medicinal …, 2011 - ACS Publications
Epigenetic mechanisms of gene regulation have a profound role in normal development and
disease processes. An integral part of this mechanism occurs through lysine acetylation of …

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

…, C Chung, P Bamborough, IJ Uings… - Journal of medicinal …, 2013 - ACS Publications
The bromo and extra C-terminal domain (BET) family of bromodomains are involved in binding
epigenetic marks on histone proteins, more specifically acetylated lysine residues. This …

[HTML][HTML] Mapping of HKT1; 5 gene in barley using GWAS approach and its implication in salt tolerance mechanism

KM Hazzouri, B Khraiwesh, K Amiri, D Pauli… - Frontiers in Plant …, 2018 - frontiersin.org
Sodium (Na + ) accumulation in the cytosol will result in ion homeostasis imbalance and
toxicity of transpiring leaves. Studies of salinity tolerance in the diploid wheat ancestor Triticum …

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

…, MV Haase, SN Farrow, IJ Uings… - … of Physiology-Lung …, 2007 - journals.physiology.org
Fluticasone furoate (FF) is a novel enhanced-affinity glucocorticoid that has been developed
as topical therapy for allergic rhinitis. The pharmacological properties of FF have been …

Glucocorticoid-induced osteopenia in the mouse as assessed by histomorphometry, microcomputed tomography, and biochemical markers

…, J Mackintosh, BP Hayes, A McLaren, IJ Uings… - Bone, 2002 - Elsevier
… , we carried out a series of experiments using BALB/c mice given daily intraperitoneal
doses … trabeculae in the distal femur, as measured using microcomputed tomography (micro-CT). …

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

DJ Mole, SP Webster, I Uings, X Zheng, M Binnie… - Nature medicine, 2016 - nature.com
… We made cDNA using a Quantitect kit applied to RNA extracts of tissue made using
microRNAEasy kits (Qiagen). We used inventoried TaqMan assays for mouse Kmo in a standard …

Cytokine-specific transcriptional regulation through an IL-5Rα interacting protein

N Geijsen, IJ Uings, C Pals, J Armstrong, M McKinnon… - Science, 2001 - science.org
… The immunoprecipitated complexes were visualized by Western analysis usingusing
GST-syntenin fusion proteins. The associated IL-5Rα was visualized by Western blotting using

Accounting index of COVID-19 impact on Chinese industries: A case study using big data portrait analysis

P He, H Niu, Z Sun, T Li - Research on Pandemics, 2021 - taylorfrancis.com
The novel coronavirus (COVID-19) outbreak has become a global pandemic and has greatly
impacted the world economy. This article adopts the financial data of Listed companies in …

[PDF][PDF] History, presence and perspective of using plant extracts as commercial botanical insecticides and farm products for protection against insects–a review.

R Pavela - Plant Protection Science, 2016 - researchgate.net
… History of using botanical insecticides Although the history of using BIs has not been mapped
very well, we do know from various existing historical sources that in Europe, the use of …