Protein kinase C–dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD (P) H oxidase
…, H Sumimoto, H Utsumi, H Nawata - Journal of the …, 2003 - journals.lww.com
… activation of NAD(P)H oxidase may be an essential … In contrast, attention is increasingly
focused on NAD(P)H oxidase … activation of NAD(P)H oxidase may be an essential mechanism …
focused on NAD(P)H oxidase … activation of NAD(P)H oxidase may be an essential mechanism …
Anti-Inflammatory properties of antipsychotics via microglia modulations: are antipsychotics a 'fire extinguisher'in the brain of schizophrenia?
…, H Horikawa, Y Seki, M Kasai, H Utsumi… - Mini reviews in …, 2011 - ingentaconnect.com
Schizophrenia is one of the most severe psychiatric diseases noted for its chronic and often
debilitating processes; affecting approximately 1% of the world's population, while its …
debilitating processes; affecting approximately 1% of the world's population, while its …
[HTML][HTML] Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of …
…, E Sonoda, C Morrison, M Hashimoto, H Utsumi… - The EMBO …, 1998 - embopress.org
… manner, as determined at 5.5 h following synchronization. The progression of the cell cycle
was the same among the four types of cells until 17 h after synchronization (data not shown). …
was the same among the four types of cells until 17 h after synchronization (data not shown). …
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
…, D Kang, N Suematsu, K Nakamura, H Utsumi… - Circulation …, 2001 - Am Heart Assoc
Mitochondria are one of the enzymatic sources of reactive oxygen species (ROS) and could
also be a major target for ROS-mediated damage. We hypothesized that ROS may induce …
also be a major target for ROS-mediated damage. We hypothesized that ROS may induce …
Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium
T Ide, H Tsutsui, S Kinugawa, H Utsumi… - Circulation …, 1999 - Am Heart Assoc
… To inhibit endogenous peroxidase, the sections were incubated with 0.3% H 2 O 2 in methanol
for 30 minutes. After rinsing in 0.01 mol/L PBS, the sections were incubated with normal …
for 30 minutes. After rinsing in 0.01 mol/L PBS, the sections were incubated with normal …
Neurotransmitters, psychotropic drugs and microglia: clinical implications for psychiatry
…, Y Seki, K Hayakawa, H Utsumi… - Current medicinal …, 2013 - ingentaconnect.com
Psychiatric disorders have long and dominantly been regarded to be induced by disturbances
of neuronal networks including synapses and neurotransmitters. Thus, the effects of …
of neuronal networks including synapses and neurotransmitters. Thus, the effects of …
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD (P) H oxidase in cultured …
…, M Naruse, H Sano, H Utsumi, H Nawata - Diabetes, 2000 - Am Diabetes Assoc
Recent studies have revealed that vascular cells can produce reactive oxygen species (ROS)
through NAD(P)H oxidase, which may be involved in vascular injury. However, the …
through NAD(P)H oxidase, which may be involved in vascular injury. However, the …
Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium
…, S Hayashidani, K Ichikawa, H Utsumi… - Circulation …, 2000 - Am Heart Assoc
… H 2 O 2 and ·O 2 − . Further, ·O 2 − produced in normal myocardium in the presence of antimycin
A (mitochondrial complex III inhibitor) could reproduce the increase of H … 2 − and H 2 O …
A (mitochondrial complex III inhibitor) could reproduce the increase of H … 2 − and H 2 O …
[HTML][HTML] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
…, K Kobayashi, S Ito, H Utsumi, H Wakui… - Nature …, 2019 - nature.com
… means of C11BODIPY staining 25 after 24 h CSE treatment in HBECs. C11BODIPY staining
… 1 h pretreatment with DFO significantly reduced the labile iron pool in HBECs, irrespective …
… 1 h pretreatment with DFO significantly reduced the labile iron pool in HBECs, irrespective …
Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress
…, T Ide, N Suematsu, S Satoh, H Utsumi… - Circulation …, 2000 - Am Heart Assoc
Oxidative stress might play an important role in the progression of left ventricular (LV) remodeling
and failure that occur after myocardial infarction (MI). We determined whether reactive …
and failure that occur after myocardial infarction (MI). We determined whether reactive …