[HTML][HTML] Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

H Flament, M Rouland, L Beaudoin, A Toubal… - Nature …, 2021 - nature.com
… i, Kinetics of IFNA, IFNB, IL1B, IL6, IL7, IL10, IL15 and IL18 mRNA relative levels in SARS-CoV-2-infected
macrophages from six healthy donors at 24 h, 48 h and 96 h after infection (n = …

Human blood monocytes are able to form extracellular traps

…, B Noël, Y Gallais, N Szely, H Flament… - Journal of leukocyte …, 2017 - academic.oup.com
… Neutrophils classically release NETs within 3 h after stimulation by PMA, a potent protein …
Human blood monocytes, along with neutrophils and moDCs, were stimulated for 3 h at 37C …

[HTML][HTML] Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

SB Mkaddem, A Murua, H Flament… - Nature …, 2017 - nature.com
… (1 µg/ml) for 1 h for monocytic cell lines and 18 h for Ramos. For ITAM signaling, cells were
… F(ab′) 2 at 37 C for 18 h for cytokine measurement. For kinase inhibitor experiments, cells …

[HTML][HTML] Efficacy of severe acute respiratory syndrome coronavirus-2 vaccine in patients with thoracic cancer: a prospective study supporting a third dose in patients …

…, VM Ferré, G Soussi, C Charpentier, H Flament… - Journal of Thoracic …, 2022 - Elsevier
Introduction Coronavirus disease 2019 resulted in a 30% mortality rate in patients with
thoracic cancer. Given that patients with cancer were excluded from serum antisevere acute …

[HTML][HTML] Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

R Alonso, H Flament, S Lemoine, C Sedlik… - Nature …, 2018 - nature.com
… Luciferase expression was determined after 72 h in cellular lysates, using a Luciferase
Reporter Assay (Promega) and expressed as relative light units (RLU) according to the …

New therapeutic perspectives for IgA nephropathy in children

A Cambier, PJ Gleeson, H Flament, MB Le Stang… - Pediatric …, 2021 - Springer
… , including the CFHR3 and CFHR1 genes, encoding factor H-related protein 3 and 1, has …
of the factor H-related proteins to inhibit the regulatory function of Complement Factor H (CFH), …

Primary brain tumour presenting as spontaneous intracerebral haemorrhage

P Kothbauer, K Jellinger, H Flament - Acta neurochirurgica, 1979 - Springer
In an autopsy series of 430 spontaneous intracerebral haematomas 44 cases, or 10.2 percent,
were caused by a proved neoplasm, including 21 anaplastic gliomas, 17 metastases, 2 …

[PDF][PDF] CD89 is a potent innate receptor for bacteria and mediates host protection from sepsis

…, L Abbad, N Chavarot, MB Le Stang, H Flament… - Cell reports, 2019 - cell.com
… IL-1 6 h after bacterial … 48 h postinfection compared with littermates (Figure 5E). In contrast,
IL-6 levels significantly increased in littermates compared with transgenic mice 6 h and 48 h

Protective role of mouse IgG1 in cryoglobulinaemia; insights from an animal model and relevance to human pathology

…, M Hurtado-Nedelec, H Flament… - Nephrology Dialysis …, 2016 - academic.oup.com
Strait et al. described a novel mouse model of cryoglobulinaemia by challenging mice
deficient in the immunoglobulin (Ig)G1 subclass (γ1 − mice) with goat anti-mouse IgD [ 5 ]. The …

Extrathymic induction of Foxp3+ regulatory T cells declines with age in a T‐cell intrinsic manner

…, C Kuhn, M Lalfer, H Flament… - European journal of …, 2013 - Wiley Online Library
… first cell division as evidenced at 36 h (Fig. 2E and F). At 36 or 48 h, iTreg cells derived from
young … 2H), a result identical to the one obtained with polyclonal Tconv cells in response to …